The aim of this study was to evaluate the efficacy of low-level laser therapy (LLLT) and alpha-lipoic acid (ALA) in the treatment of burning mouth syndrome (BMS) and secondary oral burning (SOB) by unstimulated sialometry, symptom assessment, and measurement of salivary TNF-α levels. Forty-four patients were randomized into four treatment groups: BMS/laser (n = 10), BMS/ALA (n = 5), SOB/laser (n = 15), and SOB/ALA (n = 14). The control group consisted of eight healthy female subjects. Unstimulated salivary flow was measured before and after treatment, and the collected saliva was stored at - 20 °C for the analysis of TNF-α. Symptoms were evaluated before and after treatment using a pain visual analog scale. Most patients were women (81.8%) during menopause (72.2%). LLLT and ALA were efficient in increasing salivary flow only in BMS but provided symptom relief in both conditions. TNF-α levels did not differ between patients with BMS and SOB or between those patients and the control group. No differences were observed in posttreatment TNF-α levels in either condition. The results of this study suggest that LLLT and ALA are efficient therapies in reducing burning mouth symptoms, with LLLT being more efficient than ALA.
The degree of dysplasia in AC was not statistically associated with gender, age, ethnicity, occupational exposure to sunlight, or clinical appearance. This study provides some support for the hypothesis that clinicopathologic features are not related to the degree of dysplasia in AC.
Background Florid cemento-osseous dysplasia (FCOD) has been described as a condition that characteristically affects the jaws of middle-aged black women. Radiographically, FCOD appears as dense, lobulated masses, often symmetrically located in various regions of the jaws. FCOD is usually asymptomatic. In severe cases, focal expansion may occur due to infection. Management of the symptomatic patient is more difficult due to the avascular nature of the lesion which contributes to susceptibility severe infection, bone sequestration, and osteomyelitis when surgery is performed. Case report This paper presents a rare case of severe FCOD; the black woman patient was diagnosed based on clinical and radiographic findings and treated conservatively. The examination of panoramic radiographs revealed a multiple sclerotic masses with radiolucent borders, found in the mandible and maxilla which were symmetrical at presentation. The patient continuous with the follow-up. Discussion This report confirms that a diagnosis can be made with accurate clinical and radiographic assessment. The correct selection of treatment for FCOD depends on this information.
BACKGROUNDActinic cheilitis (AC) is a potentially malignant disorder of the
lip caused by chronic exposure to ultraviolet radiation from the sun.OBJECTIVESTo evaluate the clinical, demographic, morphological and therapeutic management in
AC cases data associating to the histopathological grading.METHODSDemographic, clinical and management data of 161 patients with AC were analyzed.
In biopsied cases, two calibrated examiners performed histopathological grading by
binary system.RESULTSThere was a prevalence of males (79.5%), aged 40 years or older (77.5%),
light-skinned (85.7%), experiencing occupational exposure to sunlight (80.3%),
with AC presenting clinically as white lesions (33.6%). Conservative treatment was
adopted in 78 cases and biopsy in 83 cases (60.2% graded as low-risk AC). There
were no significant associations between histopathological grading and gender (p=
0.509), age (p=0.416), ethnicity (p=0.388), occupational exposure to sunlight
(p=1.000) or clinical presentation (p=0.803).CONCLUSIONThis study reinforces the hypothesis that demographic and clinical characteristics
of AC are not related to histopathological grading. Advice on protection from sun
exposure should be encouraged to avoid progression of AC and invasive
therapies.
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