In this study, Benchmark solutions are derived for the problem of two-dimensional laminar flow of air in a square cavity which is heated on the left, cooled on the right and insulated on the top and bottom boundaries. The temperature differences between the hot and cold walls are large. Neither Boussinesq nor low-Mach number approximations of the Navier-Stokes equations are used. The ideal-gas law is used and the viscosity is given by Sutherland's law. A constant Prandtl number is assumed. The computational method is completely described by Vierendeels et al. Grid converged results with an accuracy of 4 up to 5 digits are obtained for different Rayleigh numbers and temperature differences.

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A two-dimensional axisymmetric computer model is developed for the simulation of the filling flow in the left ventricle (LV). The computed results show that vortices are formed during the acceleration phases of the filling waves. During the deceleration phases these are amplified and convected into the ventricle. The ratio of the maximal blood velocity at the mitral valve (peak E velocity) to the flow wave propagation velocity (WPV) of the filling wave is larger than 1. This hemodynamic behavior is also observed in experiments in vitro (Steen and Steen, 1994, Cardiovasc. Res., 28, pp. 1821-1827) and in measurements in vivo with color M-mode Doppler echocardiography (Stugaard et al., 1994, J. Am. Coll. Cardiol., 24, 663-670). Computed intraventricular pressure profiles are similar to observed profiles in a dog heart (Courtois et al., 1988, Circulation, 78, pp. 661-671). The long-term goal of the computer model is to study the predictive value of noninvasive parameters (e.g., velocities measured with Doppler echocardiography) on invasive parameters (e.g., pressures, stiffness of cardiac wall, time constant of relaxation). Here, we show that higher LV stiffness results in a smaller WPV for a given peak E velocity. This result may indicate an inverse relationship between WPV and LV stiffness, suggesting that WPV may be an important noninvasive index to assess LV diastolic stiffness, LV diastolic pressure and thus atrial pressure (preload).

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