Rasmussen syndrome is characterized by continuous partial seizures with progressive neurological/cognitive impairment. Currently the only effective treatment is surgery (hemispherectomy). The objective of our study is to detect the exact epileptogenic focus through the analysis of multimodal noninvasive and innocuous functional neuroimaging. The subject is a 5-year-old female patient with Rasmussen encephalopathy. Continuous and simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) was recorded. The sources of background and paroxysmal activity of EEG were computed by low resolution electromagnetic tomography (LORETA). Image analysis (SPM: statistic parametric mapping) was obtained for the areas where statistically significant differences in the fMRI BOLD response were computed, and the results from both techniques were compared. The main source of paroxysmal activity by EEG analysis was found in the anterolateral left hemisphere, with a significant increase in absolute and relative energies of slow frequency bands (theta-delta): Z > or = 3. The fMRI BOLD signal (basal vs. paroxysmal activity) was significantly different in the same region (t-test > or = 2.39). The generators of propagated paroxysmal activity were found in similar areas for both techniques. In conclusion, simultaneous EEG-fMRI recording allows the analysis of two harmless functional neuroimaging techniques separately and together in the same time period. In our case, it allowed the accurate delineation of epileptogenic foci and areas of spread with high spatiotemporal resolution, which is crucial for epilepsy surgery.

OBJETIVO: Evaluar las características del trabajo de parto, parto y resultados perinatales de las pacientes que fueron inducidas con misoprostol intravaginal. MATERIALES Y MÉTODOS: Estudio descriptivo y retrospectivo desarrollado en el Departamento de Ginecología y Obstetricia del Hospital Nacional Cayetano Heredia durante el período julio 2003 a junio 2004. Se evaluó las historias clínicas de 139 pacientes con indicación de terminar gestación y a las que se había administrado una dosis de 25 microgramos de misoprostol intravaginal. RESULTADOS: Se obtuvo 113 partos vaginales, de los cuales 85 (61,2%) ocurrieron antes de las 24 horas, observándose un menor tiempo en las multíparas (17,4 ± 10,4 horas) versus las nulíparas (21,1 ± 13,3 horas); 58 (41,7%) pacientes sólo requirieron 1 dosis de misoprostol para tener un parto vaginal. La tasa de ceráreas fue 18,7% (26 casos), siendo la causa principal patrón no tranquilizador en 8 pacientes (30,8%). hubo 2 casos de taquisistolia (1,4%) y 1 de síndrome de hiperestimulación (0,7%). El 20% de partos presentó líquido amniótico meconial. hubo 1 (0,7%) caso de Ápgar <7 a los 5 minutos. Se hospitalizó 4 neonatos (2,8%). No hubo muerte materna ni neonatal. CONCLUSIONES: El uso de misoprostol intravaginal es útil para la inducción del trabajo de parto. Se presentaron tasas bajas de efectos adversos maternos y perinatales.