FEATURE AT A GLANCE: This case study describes the user-centered redesign of a laparoscopic instrument handle for Cardinal Health. A multidisciplinary team designed a new handle that addressed multiple ergonomic shortcomings and enabled surgeons to perform procedures with greater comfort, safety, and efficiency. Improvements included a flexible grip to allow palming or use of finger rings; broad, contoured surfaces that provided comfort and avoided pressure points; a larger rotation knob with ribs to aid grip, especially with wet gloves; and a tapered shape to accommodate a wide range of finger lengths and grip styles.