Objectives: To conduct a systematic review and meta-analysis to assess whether individuals with nonsyndromic orofacial clefts (OCs) display a higher frequency of dental anomalies (DAs) when compared with individuals without OCs. Methods: A literature search of indexed databases (PubMed, Cochrane, Web of Science, Embase, Scopus, and LILACS) was conducted without language restriction up to and including February 1, 2020. Cross-referencing was used to further identify articles. Several cleft teams across the United States and Europe were contacted to obtain unpublished data. The eligibility criteria were observational studies with original data that statistically compared individuals with OC without syndromes and those without OC on any type of DA in primary and/or permanent dentition. Random effects meta-analysis through the Mantel-Haenszel estimator was used to evaluate the association between OC and DA based on odds ratios (ORs) with 95% confidence intervals (CIs). Results: The literature search generated 933 records, and 75 full-text articles were reviewed. Twenty-six studies encompassing 15,213 individuals met the inclusion criteria. The meta-analysis revealed statistically significant associations between OC and agenesis (OR, 14.2; 95% CI, 9.4 to 21.3), supernumerary teeth (OR, 5.7; 95% CI, 3.3 to 9.7), developmental enamel defects (OR, 5.6; 95% CI, 3.5 to 9.0), microdontia (OR, 14.8; 95% CI, 4.0 to 54.6), peg-shaped anterior teeth (OR, 12.2; 95% CI, 3.6 to 41.2), taurodontism (OR, 1.7; 95% CI, 1.0 to 2.7), tooth malposition and/or transposition (OR, 5.6; 95% CI, 2.8 to 11.5), tooth rotation (OR, 3.2; 95% CI, 1.3 to 8.2), and tooth impaction (OR, 3.6; 95% CI, 1.1 to 12.2). The OR estimates of the reviewed studies exhibited significant heterogeneity ( P < 0.0001). No association was observed between OC and fusion and/or gemination. Conclusion: Within the limitations of this study, the available evidence suggests that individuals with OCs are more likely to present with a range of DAs than their unaffected peers. Knowledge Transfer Statement: The findings of the current review suggest that individuals with orofacial clefts (OCs) are more likely to present with a range of dental anomalies than their unaffected peers. Understanding the association between OCs and dental anomalies is essential in guiding clinicians during treatment-planning procedures and is important in raising our awareness of the possible need for future dental treatment for patients with OCs.

Flood-type disturbances affect both periphyton and macroinvertebrate communities depending on their frequency, magnitude and duration, but some impacts can be mitigated by geomorphic constraints. We studied four rivers in the Adirondack Mountains; the Indian River experienced regulated flow releases creating bank-full floods four times/week whereas other study sites provided a continuum of control conditions for comparison. We sampled periphyton and macroinvertebrate communities in each river along with channel hydrology, hydraulics and geomorphology. Periphyton abundance varied seasonally and among rivers depending on nitrate concentrations and scour. Flow releases created a static mosaic of patches consisting of heavily scoured bed sediment in the thalweg (high shear stress areas-HSS) which had very low periphyton abundance; boulders and rocky shoals created low shear stress areas (LSS) supporting mats of filamentous algae. Macroinvertebrate densities were highest in HSS areas whereas LSS areas had lower macroinvertebrate densities that were more similar to reference rivers, although both LSS and HSS areas had the lowest species diversity and richness. Macroinvertebrate composition in HSS areas was dominated by filter-feeders, whereas LSS areas had more gatherers and scrapers. While all rivers had high boulder densities, the Indian River could be considered geomorphically moribundits substrate was immobile and the channel experienced no adjustments in spite of high flood frequencies. These physical characteristics help mitigate the severe hydrologic conditions that releases create because the static mosaic of low and HSS patches allow certain macroinvertebrates adapted to this level of disturbance to persist. This static mosaic is different from the shifting mosaic pattern often observed in streams following flood-type disturbances. Geomorphically moribund rivers may lack ecological sensitivity to hydrologic disturbances, and decisions to limit flow modification (e.g. recreational flow releases, hydropower generation) should consider whether assumed ecological impacts are likely to occur given local geomorphic conditions and constraints.

Aim To conduct a systematic review and to evaluate the clinical parameters for periodontal diseases in individuals with cleft lip and/or palate (CL/P). Design The authors searched six indexed databases without any linguistic limitation through July 2021. The eligibility criteria were observational studies that compared the periodontal clinical measures of individuals with CL/P to those without CL/P. A meta‐analysis was conducted using random‐effects models with inverse variance weighting. Results The literature search generated 1277 records, and 40 full‐text articles were reviewed. Twenty‐three studies comprising 3235 individuals from four continents fulfilled our selection criteria. The meta‐analysis revealed a significant difference in mean plaque index scores (MD = 0.31, 95% CI = 0.22, 0.41), gingival index scores (MD = 0.50, 95% CI = 0.24, 0.77), and periodontal pocket depth (MD = 0.64, 95% CI = 0.12, 1.16) between individuals with and without CL/P. A slight increase in clinical attachment loss was detected among individuals with CL/P; however, such an increase may have little clinical significance. Conclusions As age is positively related to periodontal disease progression, and individuals with CL/P are more likely to present with more plaque accumulation and gingival inflammation, clinicians should reinforce preventive dental care from an early age.

Most studies of organic matter transport have been conducted on small headwater streams and have found that floods strongly influence downstream transport. We studied five sites on four rivers, each with different hydrographs and flood frequencies, in the Adirondack Mountains, New York, USA, during the summer and autumn of 2005. Sites on three rivers had more natural hydrographs, whereas recreational releases in the Indian River increased discharge 10-fold and to a lesser extent in the upper Hudson River below their confluence. Fine and coarse particulate organic matter (FPOM and CPOM, respectively) transport decreased from June to August at base flow in most rivers, concurrent with summer decreases in discharge; however, during releases CPOM transport increased in the Indian River and at the downstream Hudson River site below the confluence with the Indian River. Also, in the summer there was a shift from terrestrial POM in transport in June to more filamentous algae in July and August because of sloughing of periphyton. In October, POM transport increased at most sites from August levels because of autumnal leaf inputs. In summer 2006, we sampled all sites during and after a natural flood, and both FPOM transport and CPOM transport were highest in rivers with more natural hydrographs (>10,000% increase from base-flow transport levels after the flood) than in the Indian and downstream Hudson sites ($1000% increase or less). Our results suggest that recreational releases do reduce POM sources from floodplain and benthic habitats, based on lower POM transport during a natural flood.