Statins are widely used medications for the treatment of hypercholesterolemia, as well as prevention of cardiovascular disease. We report two patients with type 1 diabetes who developed autoimmune hepatitis after the administration of statin. The first patient developed the marked elevation of liver enzymes 6 months into atorvastatin therapy. The second patient developed liver dysfunction 8 months after the initiation of rosuvastatin therapy. Liver biopsies in both patients showed either portal, interface and lobular hepatitis or a piece‐meal necrosis with lymphocytes and plasma cell infiltration that were compatible with autoimmune hepatitis. Then, both patients were started on prednisolone, to which they responded well. Liver biopsy is to be considered for type 1 diabetes patients if there is no improvement of liver dysfunction after discontinuation of statins.
Umbilical cord rupture (UCR) in utero is a very rare and critical emergency that can cause fetal death within minutes. A 38-year-old nulliparous woman was admitted at 39 weeks in labour. Sudden watery vaginal discharge and bleeding with a rapid drop in the fetal heart rate to 60 beats/min necessitated an emergency caesarean section. A male infant weighing 2632 g was delivered 21 min after the onset of bradycardia; Apgar scores were 0 and 1 at 1 and 5 min, respectively. He was extremely pale; the umbilical arterial blood pH was 6.89 and haemoglobin was 9.0 g/dL. The umbilical cord had a velamentous insertion and was lacerated, with haemorrhage in the outer layer of an umbilical artery close to the placental end. The presentation was typical of UCR: vaginal bleeding following the rupture of membranes. Prompt diagnosis of UCR and termination of pregnancy are essential for fetal survival.
Main Results: The mean age of the women in this study was 36.5 ± 4.2 years and 163 (81.9%) were nulliparous. Malignancy was detected postoperatively in 5 of the 199 (2.5%) women. One woman underwent an additional operation, whereas the other 4 received medroxyprogesterone acetate and continued with treatment for infertility. Notably, 70 of 122 (57.4%) women successfully conceived within a year of surgery; however, among these 70, miscarriage occurred in 10 women. Detailed obstetric data were available for 46 women with live births following surgery. Among these 46 women, 19 underwent a cesarean section. No detrimental effects were observed on reproductive and obstetric outcomes. Conclusions: Hysteroscopic surgery was safely and effectively performed in women with infertility admitted to our hospital. Hysteroscopic surgery may contribute to successful treatment of infertility in women with intrauterine lesions.
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