Background: Premature ventricular contraction (PVC) is a frequent kind of arrhythmia that affects around 1% of the general population. While PVC most frequently impairs ventricular function in structurally normal heart, retrograde ventriculo-atrial conduction can occur in people with PVC. These retrograde atrial activations may mimic pulmonary vein-derived atrial ectopies. As a result, PVC may raise the risk of atrial fibrillation (AF) by retrograde ventriculo-atrial conduction. The Four-Dimensional Automated Left Atrial Quantification (4D Auto LAQ) tool is a left atrial analytical approach that utilizes three-dimensional volume data to quantify the volume, as well as LA longitudinal and circumferential strains. The purpose of this study was to determine if clinical diagnosis of PVC is connected with abnormal LA function as determined by LA strain evaluation utilizing a 4D Auto LAQ compared to the healthy population.

Background Premature ventricular contraction (PVC) is a frequent kind of arrhythmia that affects around 1% of the general population. While PVC most frequently impairs ventricular function in structurally normal hearts, retrograde ventriculo-atrial conduction can occur in people with PVC. These retrograde atrial activations may mimic pulmonary vein-derived atrial ectopies. As a result, PVC may raise the risk of AF by retrograde ventriculo-atrial conduction. The Four-Dimensional Automated Left Atrial Quantification (4D Auto LAQ) tool is a left atrial analytical approach that utilizes three-dimensional volume data to quantify the volume, as well as LA longitudinal and circumferential strain. The purpose of this study was to determine if clinical diagnosis of PVC is connected with abnormal LA functions as determined by LA strain evaluation utilizing a 4D Auto LAQ compared to the normal population. Methods 58 patients with frequent PVCs were enrolled in the research, along with 53 healthy volunteers as a control group. Imaging was performed using the GEvivid E95 ultrasonic diagnostic instrument (GE Healthcare; Vingmed Ultrasound, Horten, Norway) equipped with an M5S probe (frequency range: 1.5–4.6 MHz) and a 4V probe (frequency range: 1.5–4.0 MHz). Images were imported into and selected for analysis using the EchoPAC203 software (GE Healthcare). The analysis mode was selected, followed by the volume and 4D Auto LAQ submodes. Following that, the sample point was positioned in the center of the mitral orifice in each of the three planes. The'review' function was used to acquire the LA parameters measured by 4D Auto LAQ, including volume and strain parameters. Results The maximum left atrial volume (LAVmax) and minimal left atrial volume (LAVmin) were signifcantly higher in patient group (38.91±9.72 vs. 46.31±10.22, 17.75±4.52 vs. 23.10±7.13 respectively, all p values <0.001).On the other hand left atrial reservoir longitudinal strain (LASr), conduit longitudinal strain (LAScd), contraction longitudinal strain (LASct), reservoir circumferential strain (LASr-c), conduit circumferential strain (LAScd-c), and contraction circumferential strain (LASct-c) were signifcantly lower in patient group (26.64±5.64 vs. 19.16±4.58, −19.53±3.72 vs. −11.28±3.47, −10.34±1.56 vs. −4.59±1.49, 30.72±4.04 vs. 19.31±2.60, −19.91±1.78 vs. −13.38±2.85, −15.89±6.37 vs. −9.24±1.63, respectively all p values <0.001). Conclusion The present study found that premature ventricular contractions can lead to atrial remodeling as well as ventricular remodeling in patients with PVC and 4D LAQ technology can quantitatively evaluate atrial myocardial function and detect these changes early. Funding Acknowledgement Type of funding sources: None.

Background Premature ventricular complex (PVC) is seen in most individuals. It has been shown that the kinetics‐tracking index or Kawasaki‐Tanaka index (KT index) strongly predicts pulmonary capillary wedge pressure (PCWP) by noninvasively. KT index was defined as log10 (active LAEF/minimum LAV index). We goaled to assess PCWP non‐invasively in patients with frequent PVCs with normal left ventricular systolic functions and to evaluate whether there is an increase in PCWP before systolic and diastolic functions are impaired. Methods About 55 patients with frequent PVCs as a patient group and 54 healthy volunteers as a control group were involved to the study. After the conventional echocardiographic examination, the vendor‐independent software system (EchoPAC version 202) was used to obtain the time‐left atrial volume (LAV) curve. total left atrial emptying function (LAEF), passive LAEF, and active LAEF were calculated to evaluate phasic left atrial (LA) function. In this study, ePCWP was calculated using the KT index, and KT index results and other echocardiographic parameters were compared between study groups. Results LA anterior‐posterior dimension, LA maximum volume index, and LA minimum volume index were significantly larger in the patient group (all p values < .001). Total LAEF were significantly reduced in patients with frequent PVC (p < .001). Estimated pulmonary capillary wedge pressure (ePCWP) by KT index was significantly higher in patients with frequent PVCs (p < .001). Conclusions : Patients with frequent PVC had increased ePCWP as assessed by KT index.