The noise in the marine engine room has always been a major cause of disturbance and damage to sailors’ physical and mental health; however, the antinoise countermeasures were being ignored by the industry. To further reduce the noise in the marine engine room, the system structure of active noise control (ANC) and the theoretical basis of the least mean square (LMS) and filtered X least mean square (FXLMS) algorithm are studied. Based on the FXLMS algorithm ANC system, the simulation study of active noise control in the marine engine room of a multigas carrier is carried out. According to the simulation results by the diagrams plotted on the time domain and spectrum, the ANC systems with the FXLMS algorithm can effectively reduce the noise in the marine engine room by about 20 dB, especially for the peak low-frequency range of 20–500 Hz with a large antinoise effect.