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I n t r o d u c t i o n : Italy is an exception to the association of increasing Latitudinal prevalence of multiple sclerosis (MS) with temperature. This is noteworthy because even though northern Italy's average yearly temperature is significantly colder than southern Italy's MS rates are lower instead of higher. If the reason for this inverse epidemiology of MS were determined it would give important insight as to the causes of MS. A i m : This study was done to determine if variation towards a particular temperature was responsible for MS prevalence rates in Italy.

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I n t r o d u c t i o n : Analy�ing whether genetic polymorphisms proven responsi-Analy�ing whether genetic polymorphisms proven responsible for known genetic conditions are equal in incidence to the prevalence of those conditions may demonstrate a means to identify polymorphisms responsible for genetic conditions without a known genetic basis. Performing the same analysis on the temperature sensing region of the TRPM8 receptor in relation to multiple sclerosis (MS) could provide evidence of a genetic basis for MS in the TRPM8 receptor.A i m : To test if correlation between the incidence of a genetic polymorphism and the prevalence of a genetic-linked condition in a large population can identify a polymorphism that could be associated with MS. M a t e r i a l s a n d m e t h o d s : Prevalences of genetic conditions with known genetic polymorphism responsible for that condition were matched to the genetic incidence of the polymorphism proven to cause that condition. The model was then used to identify MS candidate polymorphisms in the S4-S5 region of TRPM8. The University of California Southern California Genome Browser was used for this comparison to identify polymorphism incidence rates.Results and discussion: Two polymorphisms, Rs28902201 on exon 19 and Rs149328116 on exon 20, were identified as candidate polymorphisms for MS. Other polymorphisms at these loci can contribute to the overall prevalence of MS. Rare variants that have the same genetic effect as the predominant polymorphism responsible for a condition can affect local populations significantly.C o n c l u s i o n s : Rs28902201 and Rs149328116 are candidate variants for MS based on their incidence in the population and the similarity of these incidences to MS prevalence rates.