This experimental study showed that oxidative stress and NO contributed to the pathogenesis of hyperoxia-induced lung injury, and that resveratrol had a preventive effect on hyperoxic lung injury through its anti-inflammatory and antioxidant properties.

Bernard-Soulier syndrome is an autosomal recessive coagulopathy characterized by thrombocytopenia, prolonged bleeding time and large platelets. Because of the rarity of this disease, standard perioperative treatment protocols have not been developed and there are not enough available data for the management of surgical procedures. In this case, we successfully performed adenoidectomy and tonsillectomy and circumcision surgery concurrently under the preventive and intermittent transfusion of platelets. During hospitalization, no intraoperative or postoperative bleeding complications occurred.

Acute rheumatic fever (ARF) is an inflammatory disease that occurs following an infection with certain strains of group A beta-hemolytic streptococci. Despite dramatic falls in the incidence, Acute Rheumatic Fever remains a major cause of morbidity and mortality associated with acquired heart disease in developing countries. Infective endocarditis (IE) is defined as a microbial infection of the endothelial surface of the heart. IE occurs most frequently in patients with chronic rheumatic heart disease. As far as we know, the simultaneous occurrence of both conditions has not been previously reported. References to our outpatient clinic with complaints of fever and joint pain, clinical and laboratory findings suggestive of infective endocarditis fits both with both the ARF and remitted entirely with appropriate treatment, as far as we know, we think that this is not a case of our similar event in the literature. Here we present a case of a fifteen-year-old girl with concurrent acute rheumatic fever and infective endocarditis.

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Causes of chest pain in children, rarely due to cardiac disease and usually described as idiopathic, account for 20% to 45% of all cases. In this study, we investigated the frequency of gastroesophageal reflux in children with noncardiac chest pain and the characteristics of the pain. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Children with at least two episodes per month of chest pain for a maximum of six months were enrolled in the study. After diagnostic evaluation excluded a cardiac source of chest pain, all patients underwent 24-hour pH monitoring. Characteristics of chest pain and other symptoms were recorded daily by the patients or their parents using the symptom diary. Lansoprazole treatment was administered to patients diagnosed as having gastroesophageal reflux disease. Then, the results of the lansoprazole treatment were evaluated on the basis of the presence of chest pain and other symptoms at the second month after the completion of therapy. R Re es su ul lt ts s: : Thirty-one children (17 boys and 14 girls) aged between eight and 18 years (11.6±2.4 years) with the primary complaint of chest pain were studied. Based on the 24-hour pH monitoring test results, eight patients (25.8%) for distal sensor and six patients (19.4%) for proximal sensor were defined as Gastroesophageal Reflux Disease (GERD)-positive. No significant difference was noted for characteristics of chest pain and other symptoms between the GERD-positive and GERD-negative groups. All GERD-positive children became symptom-free after the two-month lansoprazole therapy. C Co on nc cl lu us si io on n: : The symptoms of GERD-induced chest pain are often non-specific, and can be determined with certainty only by 24-hour pH monitoring, so 24-hour pH monitoring may proposed to all children with idiopathic chest pain.K Ke ey y W Wo or rd ds s: : Chest pain; gastroesophageal reflux; esophageal pH monitoring Ö ÖZ ZE ET T A Am ma aç ç: : Çocuklarda göğüs ağrısının nedeni nadiren kardiyak kökenli olur ve nedeni çoğunlukla saptanamaz. İdiyopatik göğüs ağrısı olarak tanımlanan bu durum göğüs ağrısı olgularının %20-45'ini oluşturmaktadır. Bu çalışmada göğüs ağrısı olan çocuklarda kalp kökenli nedenler dışlandıktan sonra, idiyopatik göğüs ağrısı olarak değerlendirilen çocuklarda gastroözofageal reflü sıklığını ve bu ağrının karakteristik özelliklerini araştırdık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Altı aydan uzun süre ve ayda en az iki kez göğüs ağrısı atağı olan çocukların dahil edildiği çalışmada, kardiyak nedenler dışlandıktan sonra tüm hastalara 24 saat pH monitörizasyon uygulandı. Hastalar veya ebeveynler tarafından göğüs ağrısının karakteristik özellikleri ve diğer semptomlar günlük olarak kaydedildi. Gastroözofageal reflü saptanmış olan hastaların göğüs ağrısı ve diğer semptomları iki ay süren Lansoprazol tedavisi sonrası tekrar değerlendirildi. B Bu ul lg gu ul la ar r: : Çalışmaya alınan çocukların (14 kız, 17 erkek) yaş aralığı 8 ile 18 yıl, yaş or...