INTRODUCTION: The human body is colonized by a large number of different bacterial and fungal species, with most microorganisms inhabiting the skin, oral cavity, and the lower parts of the gastrointestinal tract. AIM: The aim of this study was to investigate the species diversity of clinically significant Staphylococcus spp. isolates, obtained from blood cultures of patients with central venous catheter (CVC) following hematopoietic stem cell transplantation (HSCT) during the period January 2019-December 2020, as well as to test their susceptibility to a set of antimicrobials. MATERIALS AND METHODS: A total of 21 non-duplicate clinically significant staphylococcal isolates from blood cultures of 17 patients with implemented CVCs following HSCT were obtained. The Bactec and Phoenix automated systems (BD, USA) were used for identification and antimicrobial susceptibility testing. RESULTS: In the collected group of 21 isolates, 85.7% were coagulase-negative staphylococci (CoNS): S. epidermidis, n=12; S. haemolyticus, n=4; S. hominis, n=2, and 3 isolates were identified as S. aureus. Methicillin resistance was 85.7% and was detected only in the CoNS group. In decreasing order, the resistance rates in CoNS group were as follows: 100% for penicillin and cefoxitin >83.3% erythromycin >72.2% ciprofloxacin >61.1% gentamicin >44.4% for clindamycin and trimethoprim/sulfamenthoxazole. No resistance to vancomycin, teicoplanin, and linezolid was found. S. aureus isolates demonstrated preserved susceptibility to all antimicrobials with exception to penicillin. CONCLUSION: In the present study, CoNS were identified as the most common cause of catheter-related bloodstream infections (BSIs) in patients following HSCT, with S. epidermidis being the predominant spe-

Introduction: Propofol is an intravenous general anesthetic and sedation drug for use in the induction and maintenance of anesthesia or sedation. It is included in WHO Model List of Essential medicines and approved by the FDA (food and drug administration) in 1989. The side effects of Propofol have been studied widely in the last 25 years. They can be easily managed and that is why Propofol has become a first choice drug for the most of the anesthesiologists worldwide. This paper presents a case report of Propofol induced pulmonary edema and also a review of some of the rarest and unusual manifestations of Propofol side effects. Some of them are urine discoloration, tissue necrosis, rhabdomyolysis and postoperative pancreatitis. Methods and materials: A case summary of 18-years old woman with unusual postoperative pulmonary reaction was considered along with other documented cases. Several full-text articles were briefly analyzed for estimating the role of Propofol for a number of strange and potentially life threatening conditions. Results: Despite the low incidence rate, the presented case could be determined as a pulmonary edema due to its clinical features. Furthermore, rare drug reactions such as rhabdomyolysis, tissue necrosis, postoperative pancreatitis etc. may remain unrecognized and create diagnostic and therapeutic issues. Conclusions: Although the officially reported dangerous reaction, Propofol remains one of the best hypnotic and sedative agents. The better knowledge of the full list of drug reactions considered as rare and very rare is a guarantee of an adequate and a better therapeutic behavior.