An alternative for producing thermoplastic elastomers (TPEs) with antibacterial properties is to add copper to the polymeric matrices. This study investigates the effects of the addition of copper microparticles on the morphological, thermal, physical and mechanical behavior and antibacterial properties of a blend composed by styrene-(ethylene-butylene)-styrene triblock copolymer (SEBS) and polypropylene (PP) homopolymer. The cooper microparticles used (commercial grade, produced by electrolytical process) were dispersed in a TPE matrix composed by SEBS/PP. Two bacterial species associated with infections (Escherichia coli and Staphylococcus aureus) were used in the antibacterial assays. The incorporation of copper microparticles in TPE matrix did not promote expressive changes in the thermal, physical and mechanical properties of the compounds. The findings from antibacterial assays showed a reduction of 99.99% in bacterial counts.