Quality control of a product must be considered by all manufacturing companies to maintain product quality. One of the manufacturers of solid drug makers in the city of Medan has problems in the process of packaging/stripping. In the stripping process, there are four types of defects in X solid medicinal products that are leaky / deflated, the packaging is bad, not filled, and in the packaging, the contents are broken. To minimize defective products researchers used the Six Sigma and TRIZ methods. This study aims to determine the value of Defects Per Million Opportunities (DPMO) and sigma level and identify the risk of failure that occurs with the Failure Mode and Effects Analysis method (FMEA) and the Theory of Inventive Problem Solving (TRIZ) method as problem solvers. The result of the value of sigma level before improvement around 3.61 with the possibility of defects approximately 16981 for a million processes. Then, after improving the sigma value to 4.06 with the possibility of a process failure of 1547. The proposed improvements are training or socialization, carry out routine machine maintenance and to give the warning to monitor the performance of each operator.