The clinical features of ankylosing spondylitis ( A S ) were compared in 63 HLA-B 27 positive ( + ) and 15 B27 negative ( -) individuals with this disease. There were no differences in age at onset, functional class, degree of deformity, pain, severity of X-ray changes, or frequency of peripheral joint involvement or of reconstructive orthopedic surgery. These data demonstrated that skeletal manifestations of AS were essentially the same in B27( +) and ( -) patients, and provide no evidence for the speculation that AS in B27( -) patients is milder or is a different disease from that occurring in B27(+) patients. On the other hand, acute anterior uveitis was found to be significantly more common in B27( +) patients, a fact suggesting that the "uveitis of AS" may in fact be an independent condition occurring in B27( +) individuals, rather than a manifestation of A S per se.The association between ankylosing spondylitis (AS) and the presence of HLA-B27 is remarkably strong

Clostridium tertium could be responsible forlate metal fragment bone and joint infection.LateC. tertium metal fragment bone and joint infections requires a multidisciplinary management. Late C. tertium metal fragment bone and joint infections requires metal extraction and prolonged antimicrobial therapy for healin

Valproic acid is a reliable and comparatively safe drug in the treatment of special forms of absence seizures. Severe but very rare complications include acute liver necrosis and acute pancreatitis which may end lethally. A case of a previously unreported association of pancreatic pseudocyst and development of cholestatic icterus in conjunction with valproic acid therapy is presented. The clinical signs of icterus and chronic pancreatic failure disappeared when we terminated the therapy.