Background: Couples experience various difficulties during the infertility process. Identifying challenges is important for coping approaches and solving problems. This study aimed to determine the difficulties experienced by infertile couples and their coping strategies.Methods: This descriptive study was conducted in the infertility center of a state hospital in Istanbul between 3 June 2019 and 20 April 2020 with the participation of 319 couples. The data were collected using an Introductory Information Form and the Scale for Coping with Infertility Stress.Results: In the study, 19.7% of the women and 36.7% of their spouses were aged thirty-five and over. Compared to secondary infertile women, primary infertile women were found to have more difficulty in obtaining leave from the workplace (p = 0.018). A significant relationship was found between the couples' infertility duration (p = 0.008), perception of income (p = 0.000) and difficulty in meeting treatment costs (p = 0.001), and their mean score on the Scale for Coping with Infertility Stress. Couples considered traditional treatment as the coping behavior at the highest rate.Conclusions: While the years of infertility, income perception, and the way treatment expenses are covered are effective in the difficulties experienced by the couples, the rate of traditional treatment thought is high.