Hypertension (HT) is a common and life threating health problem worldwide leading to stroke, heart attack and renal failure. It is characterized by elevated blood pressure forced heart load. Human interleukin-6 (IL-6) and C-reactive protein (CRP) are known to be involved in inflammatory processes. IL-6

Resistance to β-lactams in Enterobacteriaceae has been increasing worldwide. This study aimed to determine the frequency of β-lactamase genes and antibiotic resistance rates of 140 extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates obtained from urinary tract infection in Ordu Province, Turkey. Isolates were identified by classic methods and by automated system. ESBL production was confirmed by double disk synergy test and antimicrobial susceptibility was investigated by disk diffusion method. All isolates were screened for β-lactamase coding genes from three groups (A, B, and D) by polymerase chain reaction. The highest rate of susceptible isolates was observed for imipenem (IPM, 99.3%) and ertapenem (ETP, 97.9%), and the highest rate of resistant isolates was observed for cefuroxime (97.9%), ceftriaxone (97.2%), and cefazolin (90.7%). In our study, bla CTX-M1-like group was the most prevalent β-lactamase (n = 109), followed by bla TEM (n = 68), bla CTX-M2 (n = 22), and bla SHV (n = 2). By contrast to low resistance rate to IPM and ETP, we determined bla NDM in 31 isolates (22.1%). In co-prevalence of bla NDM-1 and ESBL-coding genes, a low carbapenem resistance was determined. We can confirm that bla CTX-M1-types are still the most frequent β-lactamase coding gene in Turkey. Our study showed the highest prevalence of bla NDM-1 metallo-β-lactamase coding gene in ESBL-producing E. coli.