A 10-year-old boy with systemic lupus erythematosus (SLE) developed abrupt right upper quadrant pain and vomiting during the course of his active disease. Antiphospholipid antibody was negative and the C3 level was low. Abdominal sonography showed cholecystitis with sludge balls in the gallbladder. He was treated by high-dose prednisolone with ceftriaxone and metronidazole IV for 3 days but due to poor response, cholecystectomy was performed and no stone was identified. Histopathologic examination showed vasculitis in the medium-sized arteries of the gallbladder wall. He was doing well at the 9-month follow-up after the operation. This report describes the first pediatric case of SLE with acalculous cholecystitis caused by vasculitis of the gallbladder.

Diabetes mellitus is the most common endocrine disorder worldwide and it is usually along with complications such as retinopathy, neuropathy, nephropathy, and cardiovascular disease. The prevalence of diabetes is increasing and its treatment has created concerns in society. The use of herbal medicine can be helpful in the management of diabetes mellitus. The aim of this study was to investigate the protective effect of marigold hydroalcoholic extract under diabetes condition. A total of 36 male Wistar rats were randomly divided into four groups: normal control group, diabetic control group, and groups treated with 250 or 500 mg/kg hydroalcoholic extract of marigold flower during four weeks. At the end of the study, the rats were anesthetized with ketamine/xylazine, and sampling was performed through cardiac puncture. The results showed that treatment with marigold improved body weight. In addition, we determined that marigold normalized the level of CK-MB, total CK, amylase, and lipase in a dose-dependent manner. Probably these effects resulted from antioxidant property of marigold; thus we suggest that marigold flower can be useful for reduction of diabetes complication.

Context: Diabetes mellitus is the most common endocrine disease worldwide and its prevalence is increasing. The development of drugs with fewer side-effects is required when treating this disease. Thus, the objective of this study was to evaluate the use of traditional medicine and medicinal plants in this regard. The various mechanisms by which isolated extracts and herbal compounds exert their effects on different diabetes mellitus factors was investigated. Evidence Acquisition: Databases such as PubMed, Science Direct, and Web of Science (from 1990 until the present) were searched, using a detailed list of terms related to the effects and mechanism of herbal ingredients on diabetes mellitus complications. Results:The presence of secondary metabolites, such as phenols, flavonoids and alkaloids in plants, have been used as a source of medication for the treatment of many diseases, including diabetes mellitus. Following an extensive review of the literature, it was found that the secondary metabolites of plants have a wide range of anti-diabetic effects. Conclusions: Plant compounds should be isolated and their effects on diabetes mellitus and its complications examined in order to treatment for diabetes mellitus.

Context: Diabetes mellitus is the most common endocrine disease worldwide and its prevalence is increasing. The development of drugs with fewer side-effects is required when treating this disease. Thus, the objective of this study was to evaluate the use of traditional medicine and medicinal plants in this regard. The various mechanisms by which isolated extracts and herbal compounds exert their effects on different diabetes mellitus factors was investigated. Evidence Acquisition: Databases such as PubMed, Science Direct, and Web of Science (from 1990 until the present) were searched, using a detailed list of terms related to the effects and mechanism of herbal ingredients on diabetes mellitus complications. Results:The presence of secondary metabolites, such as phenols, flavonoids and alkaloids in plants, have been used as a source of medication for the treatment of many diseases, including diabetes mellitus. Following an extensive review of the literature, it was found that the secondary metabolites of plants have a wide range of anti-diabetic effects. Conclusions: Plant compounds should be isolated and their effects on diabetes mellitus and its complications examined in order to treatment for diabetes mellitus.

No abstract