A practical and efficient method is developed for efficient synthesis of quinazoline derivatives through condensation reaction of 2-aminoaryl ketone, an aldehyde, and ammonium acetate, over magnetic Fe 3 O 4 @SiO 2 -PrNH 2 -Fe 3+ NPs as a recyclable nanocatalyst, under solvent-free conditions. The asprepared nanocatalyst was characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Mild conditions, easy work up, high purity of the products, recyclability, readily availability, nontoxicity, economical, and environmental-friendly nature of the iron catalyst are the attractive features of this methodology.
Interaction of chitosan (CS) with Fe3O4, followed by embedding Cu nanoparticles (NPs) on the magnetic surface through adsorption of Cu2+, and its reduction to Cuo via NaBH4, offers a reusable efficient catalyst (Fe3O4/CS‐Cu NPs) that is employed in cross‐coupling reactions of aryl halides with phenols, which affords the corresponding diaryl ethers, with good to excellent yields. The catalyst is completely recoverable from the reaction mixture by using an external magnet. It can be reused four times, without significant loss in its catalytic activity.
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