is a rare disease which is attributed to be related with Hashimoto's thyroiditis and characterized by neurological and psychiatric symptoms, high levels of anti-thyroid antibodies, abnormal electroencephalography, and non-specific imaging findings with good response to corticosteroid therapy. In this article, we report a 72-years-old male case who experienced acute neurologic episodes including extrapyramidal findings, diplopia, dysarthria, ataxia and mild impairment in cognitive functions, followed by spontaneous remissions and was diagnosed as Hashimoto's encephalopathy in his last episode. We present this case both to emphasize this rare neurological case and the unusual case of spontaneous remission reported in Hashimoto's encephalopathy.