Background The heterocyclic compounds particularly pyridine displayed clinical and biological implementation. Pyridine scaffolds have been detected in most relevant drug molecules that included pyridine provided a great possibility for treatment. Main text Pyridine-containing compounds have increasing importance for medicinal application as antiviral, anticholinesterase activities, antimalarial, antimicrobial, antidiabetic and anticancer. This has generated concern among researchers in synthesising a variety of pyridine derivatives. Conclusion This review focuses on different pyridine targets as anticancer and their pharmacophoric elements controlling its activity.

Objective Compare optical properties of a bisacryl‐, composite‐, and ceramic‐resin restorative materials pre and post artificial aging. Methods Bisacryl‐resin (LuxaCrown [LC], DMG), resin‐composite (Filtek Supreme Ultra, [Filtek SU] 3M ESPE), and ceramic‐resin (Enamic, VITA Zahnfabrik) specimens were prepared. The L*, C*ab, and hab values were measured pre and post artificial aging to determine color stability (CIEDE2000) and changes in contrast ratio (CR), transmittance block, and relative translucency parameter. The datasets were analyzed using 2‐way ANOVA followed by pairwise comparisons. Results Color difference data showed a significant interaction between materials and treatments [F(6:60) = 375.04, P < .0001] with Enamic being most color stable material and coffee having most effect on color stability. CR data showed a significant interaction between materials and treatments [F(6:60) = 4.12, P = .0016]. LC showing most change in CR values with coffee treatment. Change in transmittance blocked by Filtek SU and LC was greater for coffee treatment than that by each of the other treatments (P < .0001). Filtek SU and LC, coffee produced a greater decrease in relative translucency than that each of the other treatments (P < .0001). Conclusions Resin‐based materials demonstrate optical properties that encourage their use for direct/indirect restorative options. Color stability and translucency of these materials are proportionally related. Clinical significance Understanding the optical properties of resin‐based materials provides help in material selection and provides insight into clinical performance and esthetic longevity. The optical stability of certain bisacryl‐resin is better than what was previously determined for these restorative materials.

SUMMARY Objective: Resin-based materials used in restorative dentistry are introduced at a fast pace with limited knowledge about their properties. Comparing properties of these materials from different restorative categories is lacking but can help the clinician in material selection. This study aimed to compare mechanical properties and wear resistance of bis-acryl-, composite-, and ceramic-resin restorative materials. Methods and Materials: Bisacryl-resin (Bis-R, LuxaCrown, DMG), composite-resin (Com-R, Filtek Supreme Ultra, 3M Oral Care), and ceramic-resin (Cer-R, Enamic, VITA Zahnfabrik) specimens were prepared for mechanical tests: fracture toughness (FT) with and without initial thermomechanical loading using a mastication simulator, flexural strength (FS), and flexural modulus (FM), compressive strength (CS), and volumetric wear loss measurement. The datasets for FT and wear resistance were each analyzed using two-way ANOVA followed by pairwise comparisons or Tukey testing as appropriate. The datasets for FS, FM, and CS were analyzed using one-way ANOVA followed by the Tukey test. Results: Analysis of FS, FM, and CS showed significant differences between materials, with all pairwise comparisons between materials showing significance. Analysis of FT resulted in a significant interaction between the material and treatment, with analysis of wear loss showing a significant interaction between the material and the number of cycles. Conclusions: Cer-R demonstrated superior FT, CS, and wear resistance compared to Bis-R and Comp-R materials. Fracture toughness of Bis-R increased after thermomechanical loading.

Interaction of compounds VI (IC50 = 8.92 nM) (A) and Vj (IC50 = 10.75 nM) (B) with key amino acids of CBS.