Aim of the work: To assess the role of radiofrequency ablation as an alternative tool in management of symptomatic benign thyroid nodules. Methods: We assessed non-functioning benign thyroid nodules in 10 patients, after treatment by radiofrequency (RF) ablation and follow-up for 6 months. RF ablation was done by Cool-Tip RF system and cooled internal electrode. Nodule volume, cosmetic and symptom scores were calculated earlier prior to treatment and throughout the follow-up. We assessed all efficacy related factors and reported complications. Results: A statistically significant difference existed between volume of nodules before the procedure with mean volume was 22.20 ± 4.61 and 1 month after with mean volume 12.38 ± 2.91with mean reduction ratio of 44.27 ± 5.77% and 3 months after the procedure with mean volume 8.08 ± 2.92 with mean reduction ratio of 65.14 ± 8.92%, also 6 months after procedure with mean volume 6.90 ± 2.78 with mean reduction ratio of 71.10 ± 7.71 %. The symptoms were significantly improved after RF ablation of patients complaining of compressive and cosmetic problems.