. Purpose:  To evaluate the efficacy and safety of deep sclerectomy in childhood glaucoma. Methods:  A prospective cohort of 120 children presenting with glaucoma to King Abdul Aziz University Hospital (KAUH) was subjected to nonpenetrating deep sclerectomy surgery (NPDS). Eventually, 57 patients had macro perforation and converted to penetrating deep sclerectomy (PDS). Intra‐operative mitomycin C (MMC) 0.2 mg/ml was used in all patients. Pre‐ and postintervention glaucoma indices were assessed. Complete success rate (CSR) was identified as achieving an end‐point of intraocular pressure <21 without any antiglaucoma medications. Data were analysed to compare pre‐ and postintervention changes and to compare both procedures. Results:  After follow‐up of 35.8 (34.5) months, NPDS procedure went smooth in 74 eyes of 63 patients. The complete success rate was 79.7%, whereas the overall success rate was 82.4%. Thirteen cases failed. The probability to survive was 74.6% after the 12th month. The mean intraocular pressure (IOP) went down to 11.5 ± 3.0 mmHg compared to 31.9 mmHg preoperatively. Comparing cases with NPDS to those with PDS, the magnitude of IOP reduction (15.8) was higher than that of the PDS (14.8); however, this difference was not statistically significant (p = 0.259). Apart from involuntary perforation of trabeculodescemetic window (TDW), neither intra‐operative nor early postoperative complications were observed. Conclusions:  Deep sclerectomy in childhood glaucoma can effectively reduce the IOP, without the occurrence of serious complications that are commonly seen after trabeculotomy or combined trabeculotomy trabeculectomy.