Background: Induction of labor is an obstetrical intervention that implies stimulation of uterine contractions before the spontaneous onset of labor, with or without rupture of membranes. When the cervix is unfavorable, cervical ripening with prostaglandins to soften and open the cervix will often commenced to induce labor. Objective: To compare 50 μg of sublingual misoprostol to 50 μg of vaginal misoprostol for induction of labour at term regarding efficacy and safety. Patients and Methods: This prospective randomized controlled trial included 104 pregnant women who were recruited