In endemic regions, include melioidosis in the routine differential diagnosis of neonates with respiratory distress, and consider early empirical ceftazidime treatment for neonates with worsening respiratory distress. K E Y W O R D SBurkholderia pseudomallei, ceftazidime, melioidosis, neonatal, Sabah Malaysia How to cite this article: Daim S, Barnad E, Johnny V, et al. Neonatal melioidosis case reports-Lessons learned. Clin Case Rep. 2020;8:171-175. https ://doi.