Measurements have been made of the concentration of protein in the spinal fluid3 in myxedema, before and after the administration of thyroid extract. These measurements are summarized in table 1. They show two things:1. In most of the cases, the protein concentration was high during the period of myxedema.2. In all but two cases, a well marked drop in the concentration occurred as the basal metabolism approached normal ( fig. 1), following the administration of thyroid extract. In the two that showed no decrease, the protein content was normal to begin with.It may be seen from table 1 and figure 1 that there were marked variations in the concentration from patient to patient, during the period of myxedema. These variations bore no relation either to the severity of the disease or to the degree of depression of the basal metabolism. There were also definite but less marked differences in the levels to which thyroid feeding depressed the protein content.These levels, in all but the first two patients, were within normal.limits (20 to 45 mgm. per 100 cc.).The change in protein concentration occurs gradually and may not be complete until some time after the basal metabolism has reached a

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