The use of closed-system drug-transfer devices (CSTD) is recommended for occupational exposure to injectable anticancer drugs. We evaluated the usability by users who actually use CSTD, the economy, and the impact on operational efciency. In a questionnaire survey of pharmacists and nurses regarding the usability of each CSTD product, the evaluation of ChemosafeLock TM was signi cantly high in both occupations in items "ease of connection between devices" and "ease of remembering operations." It was found that expanding the use of CSTD for the preparation and administration of all injectable anti-cancer drugs would increase the facility burden by 18 to 37 million yen per year. The CSTD to be adopted was selected based on the results of the questionnaire and the trial calculation of operating costs. Next, when the preparation time of cyclophosphamide and bendamustine was compared before and after the change of adoption of CSTD, the preparation time was signi cantly shortened when both drugs were prepared with the changed CSTD. The fact that the method of connecting and disconnecting devices, which is a common task for pharmacists and nurses, is simpler than that of other products is considered to be a factor in the evaluation of the questionnaire and shortened the preparation times. Medical devices have been devised to improve not only performance but also usability. These results suggest that a change of adoption to appropriate CSTD could improve the usability by pharmacists and nurses and the ef ciency of preparation and administration operations.