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The questions of creation of information technology for determination, assessment, and correction of functional sustainability of human-operator for making relevant decisions in complex human-machine systems of critical application are considered. The main negative factors which influence on functional sustainability of the work and relevant decisions-making by the human-operator in critical situations are singled out. Information technology for assessment and correction of functional sustainability of human-operator operating in critical conditions, in such areas as power engineering, gas-petrochemical, etc. are offered. These industries have specific requirements for the human factor. Consideration is given to making decisions in real time by the decision maker (DM), in conditions of uncertainty, which depends on its cognitive component, the influence of the production process factors, and the environmental factors that significantly affect the functional sustainability. Mathematical models and methods of assessing the adequate influence of factors on the psycho-physiological and cognitive capabilities of the DM through his/her identification and the formation of an individual interface for him/her, so as to ensure the maximum effectiveness of interaction with the system, to make relevant decisions have been developed. The practical results of the study of the influence of a set of factors such as: the external environment, the cognitive component, the psychological state, the information load which