Africa now stands at the threshold of development that requires a new approach to promote technological advancement and long-term economic growth. While information and communication technologies (ICTs) have been initiated in the education sector of Ghana, the technology evolution and its advancement remain sluggish due to a lack of productive ICT schemes and long-running support for ICT infrastructure. With the present global health crisis launching nationwide educational disruptions and causing numerous revisions in the system, there is a necessity for developing an understanding of the effects of these technological advancements. More importantly, the socioeconomic facet of online inclusive education demands a reevaluation to facilitate the conceptualization of effective teaching and learning activities. This chapter emphasizes that technology integration such as the application of online teaching and learning could be used to enhance digital literacy within the South African context.