This article summarizes key advances in hypnosis research during the past two decades, including (i) clinical research supporting the efficacy of hypnosis for managing a number of clinical symptoms and conditions, (ii) research supporting the role of various divisions in the anterior cingulate and prefrontal cortices in hypnotic responding, and (iii) an emerging finding that high hypnotic suggestibility is associated with atypical brain connectivity profiles. Key recommendations for a research agenda for the next decade include the recommendations that (i) laboratory hypnosis researchers should strongly consider how they assess hypnotic suggestibility in their studies, (ii) inclusion of study participants who score in the middle range of hypnotic suggestibility, and (iii) use of expanding research designs that more clearly delineate the roles of inductions and specific suggestions. Finally, we make two specific suggestions for helping to move the field forward including (i) the use of data sharing and (ii) redirecting resources away from contrasting state and nonstate positions toward studying (a) the efficacy of hypnotic treatments for clinical conditions influenced by central nervous system processes and (b) the neurophysiological underpinnings of hypnotic phenomena. As we learn more about the neurophysiological mechanisms underlying hypnosis and suggestion, we will strengthen our knowledge of both basic brain functions and a host of different psychological functions.

In the active-alert induction the subject rode a bicycle ergometcr under load, keeping eyes open while exercising and receiving suggestions of alertness. The alternate form, used in random alternation with the same subjects, consisted of the standard eye-fixation and relaxation induction of the Stanford Hypnotic Susceptibility Scale, Form B (SHSS-B). Within each session on two days during which each of the 50 subjects served, the induction procedure was followed by eight tests of responses to suggestion, from the SHSS-A and SHSS-B. The mean measured hypnotic responsiveness was independent of the type of induction. The active-alert condition was characterized by an acceleration of the rate of pedaling for the more responsive subjects. Although the subjective alterations differed between the two kinds of induction, the highly susceptible reported that in both cases altered stales were achieved.

On the basis of 14 years of empirical research conducted in a mulidimensional interactional framework, the main characteristics of different hypnosis styles are described. It is suggested that typical hypnosis styles resemble the patterns of basic intimate relationships that have mutual regulatory function. This interpretation may help to understand the healing effects of hypnosis, well known for ages, since more and more data indicate that the quality of intimate relationships plays an important role in the development and maintenance of mental and physical health. The research summarized here support the social psychobiological model of hypnosis, conceptualizing hypnosis as an altered state of consciousness that may have a socially and biologically adaptive value. Copyright © 1998 British Society of Experimental and Clinical Hypnosis

Previous studies implicate involvement of dopaminergic systems in hypnotizability and report association with the COMT Val(158)Met single nucleotide polymorphism (SNP, rs4680) demonstrating the Val/Met heterozygotes as the most hypnotizable group using the Stanford Hypnotic Susceptibility Scale. This study replicates that association using an independent sample of 127 healthy Hungarian young adults and the Waterloo-Stanford Group C Scale of Hypnotic Susceptibility. Significant association (p = .016) was found between the COMT genotypes and hypnotizability, with a clear additive effect of the Val allele: Hypnotizability scores were highest in Val/Val (5.9), intermediate in Val/Met (4.7), and lowest in Met/Met (4.1). Differences between these results and those of previous studies support recent findings suggesting an inverted-U-shaped relation between dopamine level in the prefrontal cortex and cognitive functioning. The present study replicates association of COMT Val(158)Met SNP and hypnotizability and stresses the importance of mediating factors, such as group vs. individual inductions.

In a between-lab study, a constant and steady shift was found in hypnotizability scores measured with standard scales. To investigate a time effect in a Hungarian (within-lab) sample, 613 subjects' scores on Stanford Hypnotic Susceptibility Scale, Forms A and B, 1898 subjects' self-scores, and 1713 subjects' observer-scores on the Harvard Group Scale of Hypnotic Susceptibility were analyzed. From the 1970s to 2010, a significant increase was observed in the SHSS:A and B scores of female subjects and the HGSHS:A scores of both genders. Females proved to be significantly more hypnotizable than males in a group setting but not in an individual context. Time and gender did not interact. The possible reasons for these effects on hypnotizability and the role of the testing context are discussed.