No abstract

No abstract

No abstract

About 3000 microorganisms (bacteria, Actinomyces, Zygomyces, Deuteromyces) were screened for their capacity to convert mevinolin. Absidia coerulea IDR 705 was found to produce two hydroxylated derivatives of mevinolin, 2 and 3. Compound2 is a new transformation product while compound 3 was described as a chemical modification product of mevinolini\ By combination of spectroscopic techniques, the structures of 2 and 3 were identified with j5,(5-dihydroxy-7-(l ,2-dihydro-2-hydroxymethyl-6-methyl-naphthalen-l-yl)-heptanoic acid (5-lactone and j5,^-dihydroxy-7-[1 ,2,3,5,6,7,8,8a-octahydro-3,5-dihydroxy-2,6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-l-yl]heptanoic acid (5-lactone, respectively. The inhibitory effects of the two derivatives on the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase were similar to that of mevinolin.

No abstract