A norganische C hem ie d e r U n iv ersität M ünchen, M eiserstraße 1, D-8000 M ünchen 2 D edicated to Prof. Dr. H. P. Fritz on the occasion o f his 60th birthday Z. N aturforsch. 45b, 8 1 7 -8 2 7 (1990); received N o v em b er 29, 1989 Steroid D erivatives, A m ine a n d A lcoholic C o m p o n en ts, D ichloro P latinum (II) an d P allad iu m (II) C om plexes, a-A m in o A cid A m ides an d Esters 3-(2-A m inoethoxy)estrone, 3 -(2 -am inoethoxy)estradiol, 1 7a-am inom ethylestradiol and 3-ol-17-am inoestrane react w ith co o rd in ate d activated am in o acid ligands o f p latin u m (II) and palladium (II) com plexes to give cis-a n d /ran s-C l2P t

trans‐Bis(dipeptide ester)palladium 1–6 complexes with a deprotonated amide group were obtained by dehydrochlorination of trans‐Cl2Pd(dipeptide ester)2 or by direct reaction of Na2PdCl4 with dipeptide ester in the presence of sodium methoxide. The structure of Pd(NH2CH2CONCH2CH2CO2CH3)2 (3) was determined by X‐ray diffraction. Addition of NaOCH3 to Pd[NH2C(H)(R)NCH2CH2CO2CH3]2 [R = CH(CH3)24, CH2Ph 5] results in the formation of the corresponding complexes 7, 8 with cyclic tetrapeptides which also can be directly synthesized from the dipeptide ester and Na2PdCl4.

The reactions of unprotected D-glucosamine with N-coordinated, activated amino acid ester ligands (glycine, diglycine, histidine) of platinum(II) and palladium(II) complexes afford cis- and trans- Cl2Pt(NH2CH2CONHR), trans-Cl2Pt(NH2CH2CONHCH2CONHR)2 and Cl2Pd(histNHR)2 (R = sugar residue) as products. 1,2-Diaminocyclohexane reacts with the activated esters of cis-Cl2Pt- (NH2CH2COOH)2, cis-Cl2Pt(triglyOH)2, cis-Cl2Pt(metOH) and cis-Cl2Pd(histOH) to give dinuclear complexes Cl2Pt[(gly)nNHC6H10NH(gly)n]2PtCl2 (n = 1, 3), Cl2Pt(methNHC6H10NHmeth)- PtCl2 and Cl2Pd(histNHC6H10NHhist)PdCl2.