Raman spectroscopy provides accurate and cost‐effective quality control of pharmaceuticals, which is essential for maintaining the confidence of dispensing physicians and patient's adherence to therapeutic regimens. For drug salts that contain a counter‐ion, the active pharmaceutical ingredient and counter‐ion combination is optimized for the intended therapeutic effect. Drug salts with multiple alternative counter‐ions are developed, dosed, and regulated independently and case study one demonstrates how an adulterated medication can contain a different counter‐ion than the label claim. Three additional case studies are performed that showcase how Raman spectroscopy can be applied as a cost‐effective alternative detection technique of both label claim drug and counter‐ion when compared to more commonly used HPLC‐UV methods.

The cover image is based on the Research Article Raman spectroscopy detects adulterated counter‐ions in pharmaceuticals by Evan Fuini et al., https://doi.org/10.1002/jrs.6306.