Ocular and orbital inflammation may occur in patients with metastatic melanoma receiving ipilimumab, is frequently accompanied by other IRAEs, and resolves with corticosteroid treatment, often leaving no long-term sequelae.
Purpose-To determine if hyperreflective foci (HF) and macular thickness on spectral domain ocular coherence tomography (SD-OCT) are associated with lipid levels in type 2 diabetes (T2D) patients.Methods-238 participants from four sites had fundus photographs and SD-OCT images graded for hard exudates (HE) and HF, respectively. Regression models were used to determine the association between serum lipid levels and (1) presence of HF and HE and (2) central subfield macular thickness (CSMT), central subfield macular volume (CSMV) and total macular volume (TMV).Results-All patients with HE on fundus photographs had corresponding HF on SD-OCT but 57% of patients with HF on OCT did not have HE detected in their fundus photographs. Presence of HF was associated with higher total cholesterol [(odds ratio (OR) = 1.13, 95% confidence interval (CI) = 1.01-1.27, P = 0.03] and higher low density lipoprotein (LDL) levels (OR = 1.17, This submission has not been published anywhere previously and is not simultaneously being considered for any other publication.
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Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript 95% CI = 1.02-1.35, P = 0.02) in models adjusting for other risk factors. The TMV was also associated with higher total cholesterol (p = 0.009) and triglyceride (p = 0.02) levels after adjusting for other risk factors.Conclusion-Higher total and LDL cholesterol were associated with presence of HF on SD-OCT. TMV was associated with higher total cholesterol and triglyceride levels.
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