StatementIn our current work we investigated the neurodegeneration-related and well-known neurotoxic beta-amyloid aggregate as an attenuator of autocatabolism-based organ shrinkage in an invertebrate micro-in vivo system.
AbstractInvestigation of human neurodegeneration-related aggregates of beta-amyloid 1-42 (Aβ42) on bdelloid rotifers is a novel interdisciplinary approach in life sciences. We reapplied an organ size-based in vivo monitoring system, exploring the autocatabolism-related alterations evoked by Aβ42, in a glucosesupplemented starvation model. The experientially easy-to-follow size reduction of the bilateral reproductive organ (germovitellaria) in fasted rotifers was rescued by Aβ42, serving as a nutrient sourceand peptide sequence-specific attenuator of the organ shrinkage phase and enhancer of the regenerative one including egg reproduction. Recovery of the germovitellaria was significant in comparison with the greatly shrunken form. In contrast to the well-known neurotoxic Aβ42 (except the bdelloids) with specific regulatory roles, the artificially designed scrambled version (random order of amino acids) was inefficient in autocatabolism attenuation, behaving as negative control. This native Aβ42-related modulation of the 'functionally reversible organ shrinkage' can be a potential experiential and supramolecular marker of autocatabolism in vivo.
Highlights
Bdelloids are adaptive models for studying aggregate-metabolism interactions.
Starvation causes reversible organ shrinkage in bdelloids.
The organ shrinkage is in connection with autocatabolic processes.
Beta-amyloid attenuates the starvation-induced germovitellaria shrinkage.
Human-type amyloid-aggregates are metabolism-regulators in two bdelloid species.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.