We present BVRI and unfiltered (Clear) light curves of 70 stripped-envelope supernovae (SESNe), observed between 2003 and 2020, from the Lick Observatory Supernova Search (LOSS) follow-up program. Our SESN sample consists of 19 spectroscopically normal SNe Ib, two peculiar SNe Ib, six SNe Ibn, 14 normal SNe Ic, one peculiar SN Ic, ten SNe Ic-BL, 15 SNe IIb, one ambiguous SN IIb/Ib/c, and two superluminous SNe. Our follow-up photometry has (on a per-SN basis) a mean coverage of 81 photometric points (median of 58 points) and a mean cadence of 3.6 d (median of 1.2 d). From our full sample, a subset of 38 SNe have pre-maximum coverage in at least one passband, allowing for the peak brightness of each SN in this subset to be quantitatively determined. We describe our data collection and processing techniques, with emphasis toward our automated photometry pipeline, from which we derive publicly available data products to enable and encourage further study by the community. Using these data products, we derive host-galaxy extinction values through the empirical colour evolution relationship and, for the first time, produce accurate rise-time measurements for a large sample of SESNe in both optical and infrared passbands. By modeling multiband light curves, we find that SNe Ic tend to have lower ejecta masses and lower ejecta velocities than SNe Ib and IIb, but higher 56Ni masses.

Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism. Prohibitins form a heterodimeric complex, consisting of two proteins, prohibitin 1 (PHB1) and prohibitin 2 (PHB2). They have been discovered to have crucial roles in regulating cancer and other metabolic diseases, functioning both together and independently. As there have been many previously published reviews on PHB1, this review focuses on the lesser studied prohibitin, PHB2. The role of PHB2 in cancer is controversial. In most human cancers, overexpressed PHB2 enhances tumor progression, while in some cancers, it suppresses tumor progression. In this review, we focus on (1) the history, family, and structure of prohibitins, (2) the essential location-dependent functions of PHB2, (3) dysfunction in cancer, and (4) the promising modulators to target PHB2. At the end, we discuss future directions and the clinical significance of this common essential gene in cancer.

Background-In comparison to their urban and suburban counterparts, midlife and older rural women are less likely to consume adequate fruit and vegetables (F&V). The present study aimed to examine the relationships between psychological, social, and environmental factors and F&V intake among midlife and older rural women in the United States. Methods-This cross-sectional study utilized data from 513 midlife and older rural women (mean age = 67.0, mean BMI = 26.8) living in 22 states. Linear regression models were used to examine the associations between women's daily F&V intake and cooking confidence, healthy eating self-efficacy, perceived stress, healthy eating social support, and perceived food environment. Results-Cooking confidence (p < 0.001) and healthy eating self-efficacy (p < 0.001) were positively associated with F&V intake. Perceived stress, healthy eating social support, and perceived food environment were not associated with F&V intake (p > 0.05). When all the independent variables were analyzed simultaneously, only healthy eating self-efficacy remained positively associated with F&V intake (p < 0.001). Conclusions-Findings from our study provide important information on the influences of rural women's healthy eating self-efficacy and cooking confidence on their F&V intake. Our results may be useful to inform and evaluate targeted strategies to improve the dietary health of rural women.

Objective To examine the frequency of shopping at different food sources, and the associations between shopping at different food sources and fruit and vegetable (FV) intake among upstate New York rural residents. Design Cross-sectional study. Descriptive statistics and linear mixed models were used. Setting Eighty-two rural communities in upstate New York, USA. Participants 465 adults (82.3% female, mean age = 51.5, mean BMI = 31.7). Results Within one’s community, the majority of participants reported often going to supermarkets (73.1%). Many participants sometimes or occasionally shopped at superstores (48.0%), convenience stores (57.9%), small grocery stores or local markets (57.2%), farmers’ markets or FV stores (66.6%), dollar stores (51.5%), pharmacies (46.0%), or farm stands or community supported agricultures (56.8%). Most participants had never utilized food banks or food pantries (94.0%), community gardens (92.7%), or home food delivery (91.9%). While frequent visits to farmers’ markets or farm stands were associated with higher fruit intake (P<0.001), frequent visits to food co-ops or food hubs were associated with lower fruit intake (P=0.004). Frequent visits to convenience stores (P=0.002) and dollar stores (P=0.004) were associated with lower vegetable intake. When FV intakes were combined, frequent visits to farmers’ markets or farm stands (P<0.001) were associated with higher FV intake, and frequent visits to convenience stores (P=0.005) were associated with lower FV intake. Conclusions Findings from the present study provide important insight for informing future food environment interventions related to helping rural residents to consume adequate FV.