In March 2020, the World Health Organization declared COVID-19 a worldwide pandemic. Countries introduced public health measures to contain and reduce its spread. These measures included closures of educational institutions, non-essential businesses, events and activities, as well as working from and staying at home requirements. These measures have led to an economic downturn of unprecedented proportions. Generally, as economic activity declines, travel decreases and drivers are exposed to a lower risk of collisions. However, research on previous economic downturns suggests economic downturns differentially affect driver behaviours and situations. COVID-19 pandemic effects on road safety are currently unknown. However, preliminary information on factors such as the increased stress and anxiety brought about by the COVID-19 pandemic, more "free" (idle) time, increased consumption of alcohol and drugs, and greater opportunities for speeding and stunt driving, might well have the opposite effect on road safety. Using an interactionist model we identify research questions for researchers to consider on potential person and situation factors associated with COVID-19 that could affect road safety during and after the pandemic. Collaborative efforts by researchers, and public and private sectors will be needed to gather data and develop road safety strategies in relation to the new reality of COVID-19. Health Organization, 2020). By March 2020, the WHO had declared COVID-19 a worldwide pandemic with 216 countries, areas or territories showing 10,719,646 cases and 517,337 deaths combined as of July 2, 2020 (World Health Organization, 2020). This pandemic led to a series of worldwide public health measures to contain and reduce its spread. In many countries the measures included physical distancing measures, such as the "lockdown" of educational institutions, restaurants, bars, retail and other non-essential businesses, banning public events, such as sporting events, concerts, theatre shows and encouraging or requiring teleworking from home