Automatic detection of pulmonary nodules in thoracic computed tomography (CT) scans has been an active area of research for the last two decades. However, there have only been few studies that provide a comparative performance evaluation of different systems on a common database. We have therefore set up the LUNA16 challenge, an objective evaluation framework for automatic nodule detection algorithms using the largest publicly available reference database of chest CT scans, the LIDC-IDRI data set. In LUNA16, participants develop their algorithm and upload their predictions on 888 CT scans in one of the two tracks: 1) the complete nodule detection track where a complete CAD system should be developed, or 2) the false positive reduction track where a provided set of nodule candidates should be classified. This paper describes the setup of LUNA16 and presents the results of the challenge so far. Moreover, the impact of combining individual systems on the detection performance was also investigated. It was observed that the leading solutions employed convolutional networks and used the provided set of nodule candidates. The combination of these solutions achieved an excellent sensitivity of over 95% at fewer than 1.0 false positives per scan. This highlights the potential of combining algorithms to improve the detection performance. Our observer study with four expert readers has shown that the best system detects nodules that were missed by expert readers who originally annotated the LIDC-IDRI data. We released this set of additional nodules for further development of CAD systems.

NeuroEvolution (NE) refers to a family of methods for optimizing Artificial Neural Networks (ANNs) using Evolutionary Computation (EC) algorithms. NeuroEvolution of Augmenting Topologies (NEAT) is considered one of the most influential algorithms in the field. Eighteen years after its invention, a plethora of methods have been proposed that extend NEAT in different aspects. In this paper we present a systematic literature review (SLR) to list and categorize the methods succeeding NEAT. Our review protocol identified 232 papers by merging the findings of two major electronic databases. Applying criteria that determine the paper's relevance and assess its quality, resulted in 61 methods that are presented in this paper. Our review paper proposes a new categorization scheme of NEAT's successors into three clusters. NEATbased methods are categorized based on 1) whether they consider issues specific to the search space or the fitness landscape, 2) whether they combine principles from NE and another domain or 3) based on the particular properties of the evolved ANNs. The clustering supports researchers 1) understanding the current state of the art that will enable them 2) exploring new research directions or 3) benchmarking their proposed method to the state of the art, if they are interested in comparing, and 4) positioning themselves in the domain or 5) selecting a method that is most appropriate for their problem.

No abstract

No abstract

No abstract