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Introduction. The preclinical study of the effect of chemical intoxication on the blood system's states is especially relevant for preventing and treating workers producing bromo-aromatic compounds with polytropic toxic effects m-bromaniline sulfate, in case of possible contact at the stages of its synthesis. The aim of the study to research in an experiment the toxic effect of m-bromaniline sulfate on the state of the blood system. Materials and methods. Sulfate m-bromaniline is an intermediate of the synthesis of the drug tramadol. Scientists study the toxic effect of sulfate m-bromaniline in experiments on rats. We reproduce single inhalation and subacute intragastric modes and methods of exposure. The researchers evaluated the impact of the substance on animals based on the results of peripheral blood tests. Namely: by the number of red blood cells, hemoglobin, white blood cells, analysis of the white blood cell formula. According to the indicators of biochemical tests of blood serum, morphological data of the study of the liver, kidneys, heart, stomach. We took into account the readings of the critical parameters of the pancreas and thyroid glands. Results. The results of examining animals subjected to acute inhalation intoxication and sub-acute intragastric exposure showed the same type of changes in the peripheral blood and experimental group's biochemical profile. The intake of m-bromaniline sulfate leads to a decrease in the number of red blood cells and hemoglobin against the background of increased reticulocytosis, leukocytosis. The number of eosinophils in the blood of animals exposed to poisoning decreased by almost one and a half times. We found a violation of the balance of hemoglobin fraction's content. Also reduced oxyhemoglobin, an increase in methemoglobin. Researchers discovered in the blood sulfohemoglobin in the absence of it in the control group's animals. The animals' biochemical profile revealed increased blood catalase activity against the background of its decrease in red blood cells. In the blood serum of rats primed with sulfate m-bromaniline we found an increase in bilirubin concentration. We noted an increase in the activity of aspartate aminotransferase while maintaining the same action of alanine aminotransferase. The effect of sulfate m-bromaniline at the morphological level revealed vascular disorders in all internal organs and moderately pronounced fatty degeneration of the liver and kidneys. The spleen was hyperplastic; a large amount of brown iron-containing pigment was noted intra- and extracellularly in the red pulp. Conclusions. Different receipt methods of sulfate m-bromaniline in the conditions of acute inhalation sub-acute intragastric experiments lead to some disorders. Violations have a hemotoxic character with a predominant effect on the state of the blood system. An essential element of intoxication prevention can be the correct selection of the persons entering the work contact with toxicants. Individuals with manifesting or latent iron deficiency, various hemorrhagic syndrome types, and severe forms of autonomic dysfunction represent a health risk group if possible contact with sulfate m-bromaniline.

Introduction. Cardiopulmonary disorders should be considered as a complex process, in the pathogenesis of which excess body weight can play an important role. Without timely prevention, the processes of inflammation and hypoxia, characteristic of abdominal obesity, can accelerate the development of cardiopulmonary insufficiency. This is especially relevant for workers in metallurgical industries with harmful working conditions. Materials and methods. The study included one hundred thirteen long-term labour experience workers of the main occupations of aluminum production and 66 workers of the paramilitary mine rescue brigade. The average age of metallurgists was 47.81±0.43 years, mine rescuers – 46.91± 0.53 years, p=0.213. All the subjects underwent a study of the external respiration function and echocardiography according to standard methods. Results. In persons with abdominal obesity the average values of the vital lung capacity were significantly lower: 83.59±2.19% vs. 91.16±1.31% (p=0.0021) among metallurgists and 86.43±2.67% vs. 94.63±1.43% (p=0.0041) among the workers of the paramilitary mine rescue brigade, a similar pattern was revealed in terms of the forced exhalation volume for the first second – 77.1±2.41 vs. 88.24±1.38% (p=0.00003) and 85.6±3.13% vs. 93.34±1.31% (p=0.0094), respectively. The studied average values of the indices of diastolic function of the right ventricle were typical for the development of its dysfunction in metallurgists, and also indicated the absence of the influence of abdominal obesity on them in all examined subjects. Limitations. The study was limited by the number of the examined persons undergoing periodic medical examination at the Research Institute for Complex Problems of Hygiene and Occupational Diseases. Conclusion. Lower respiratory indices were recorded in persons with abdominal obesity, while obstructive ventilation disorders were detected only in aluminum production workers. Abdominal obesity was not associated with the indices of diastolic function of the right ventricle. The tendency to the formation of diastolic dysfunction of the right ventricle had been noted in the workers of the main occupations of aluminum production.

Introduction. Obesity and cardiovascular diseases are closely related and have a high prevalence in the global population. Workers of coal mining enterprises have an increased risk of developing these pathological conditions due to working conditions and employment schedules. Social and household factors and an unhealthy lifestyle can have a negative impact on metabolic processes that lead to obesity. In this regard, the search for risk factors for these diseases and the elaboration of a prevention system based on them to preserve the health of working groups of the population are relevant. Materials and methods. The study involved three hundred eighty-five workers of coal enterprises in the South of Kuzbass including 244 miners and 141 coal pit workers. The mean age was 46.35±0.34 and 46.98±0.36 years, respectively, p=0.231. The social and household aspects and lifestyle of the workers were revealed by the questionnaire method. Ultrasound investigation of vessels was performed on the General Electric Vivid E9 system. Results. The prevalence of atherosclerosis in obese workers employed in coal pits was higher than in persons with normal weight: 58.8% vs. 40.0%, p=0.035; no such pattern was found among miners. In coal pit workers with arterial hypertension, abdominal obesity was detected in 90.9% of the cases and in 67.0% (p=0.0004) in underground miners. The studied social and household factors, except for hypodynamia, had no a significant impact on the development of obesity. Limitations. The investigation did not include individuals with proven familial hypercholesterolemia, inflammatory vascular diseases and diabetes mellitus. Conclusion. Constitutional obesity increased the atherosclerosis risk in coal pit workers and did not affect on its prevalence in underground miners. Abdominal obesity did not contribute to an increase in the prevalence of atherosclerosis among the examined subjects, but increased the risk of arterial hypertension. Among the studied social and household factors, a significant role in the development of constitutional obesity in coal pit workers is rendered by hypodynamia during non-working hours.

Introduction. Benzoic acid and its numerous derivatives are widely used in all areas of chemical production. However, there is no information about the toxic properties of a large number of benzoic acid derivatives. The purpose of the study was to study the toxic properties of several derivatives of benzoic acids in intragastric intake in an experiment.Material and methods. The following derivatives of benzoic acid were studied: 4-chlorobenzoic, 4-methoxybenzoic, p-acetoxybenzoic and 2-methoxy-5-sulfamoylbenzoic acids. The studies were performed on white laboratory rats; toxicity was studied in repeated experiments with the oral administration of substances. The condition of the animals was assessed by integrated parameters, indices of biochemical analyzes of blood serum, morphological data from a study of the liver, kidneys, heart, stomach, pancreas and thyroid glands.\Results. According to toxicometric data, 4-chlorobenzoic acid is classified as moderately hazardous, hazard class III, 4-methoxybenzoic, p-acetoxybenzoic and 2-methoxy-5-sulfamoylbenzoic acids belong to hazard class IV (low hazard). Under the subchronic administration of all the studied compounds, there was a significant increase in urea concentration, aminotransferase activity, and a decrease in catalase activity, most pronounced in poisoning with 4-chlorobenzoic and 4-methoxybenzoic acids. Morphohistological studies confirmed the predominant effect of benzoic acid derivatives on the functioning of the hepatorenal system in the animals exposed to poisoning. Microscopically fatty liver dystrophy was observed, there was a diffuse proliferation of Kupffer cells. In the kidneys, the glomeruli were enlarged in size; the lumen of the Shumlyansky-Bowman’s capsule was narrowed as a result of swelling of the capillary endothelium.Conclusion. Subchronic oral intake of 4-chlorobenzoic, 4-methoxybenzoic, p-acetoxybenzoic, and 2-methoxy-5-sulfamoylbenzoic acids leads to many disorders in the body, which are mainly of a common toxic nature with a predominant effect on the state of the hepatorenal system. The most pronounced organotoxic effect is manifested in the chlorine-containing derivative of benzoic acid - 4-chlorobenzoic acid. Due to the low toxicity of benzoic acids, chronic poisoning in the workplace is unlikely; it is possible only if the technological processes are disrupted.