Multiple clinical studies have shown that interstitial photodynamic therapy (I-PDT) is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre- and post-imaging using computed tomography (CT) with contrast may be utilized to assess the response.

We compare previously reported benzoporphyrin derivative (BPD)-mediated photodynamic therapy (PDT) results for reactive singlet oxygen concentration (also called singlet oxygen dose) on mice with simulations using a computational device, Dosie™, that calculates light transport and photokinetics for PDT in near real-time. The two sets of results are consistent and validate the use of the device in PDT treatment planning to predict BPD-mediated PDT outcomes in mice animal studies based on singlet oxygen dose, which showed a much better correlation with the cure index than the conventional light dose.

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The standard bilinear interpolation on normal maps results in visual artifacts along sharp features, which are common for surfaces with creases, wrinkles, and dents. In many cases, spatially varying features, like the normals near discontinuity curves, are best represented as functions of the distance to the curve and the position along the curve. For high-quality interactive rendering at arbitrary magnifications, one needs to interpolate the distance field preserving discontinuity curves exactly.We present a real-time, GPU-based method for distance function and distance gradient interpolation which preserves discontinuity feature curves. The feature curves are represented by a set of quadratic Bezier curves, with minimal restrictions on their intersections. We demonstrate how this technique can be used for real-time rendering of complex feature patterns and blending normal maps with procedurally defined profiles near normal discontinuities.

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