Hepatic metastasectomy in colorectal cancer is becoming a routine procedure, however the presence of extrahepatic metastatic disease worsens the life expectancy. A high-volumetric hepatic resection in case of multiple liver metastases might be performed after iatrogenic liver hypertrophy aimed to enlarge functional liver volume. Ligation or embolization of portal vein can be done. The outcome of the procedure is significantly improved using newest chemotherapy regimens and biological medications. We report a case with successful combined therapy of a 49-year-old male with colorectal cancer and bilateral extended metastatic process in liver and lungs.