No abstract

Paediatric ulcerative colitis (UC) has a tendency to run in an extensive manner, with frequent exacerbations. As a result, treatment of paediatric patients is a complex process demanding thorough evaluation, careful monitoring, and selection of appropriate medication. We present a case report of UC in an 11-year-old boy diagnosed at the age of 7 years. During 3 years of treatment many therapeutic methods were used, but none brought a long-lasting therapeutic effect. Due to exhaustion of available therapeutic options, off-label treatment with vedolizumab was introduced. Currently, in his 15th month of the therapy, the patient remains in remission. This case, in line with the available literature, indicates that there might be a need to include vedolizumab to the UC standard treatment regimens. Moreover, it should also be considered for inclusion in funding programs of national health insurance companies. It is of a crucial importance for patients because in some cases it remains the last treatment option.

Background Intussusception remains one of the most common emergencies in pediatrics. It typically occurs between six months and three years of age, but it can be observed in all age groups. Intussusception usually presents with traditionally described symptoms; however, it is believed that the older the patient, the higher the risk of an existing pathological lead point, which could be associated with less characteristic symptoms. It is crucial to make a timely diagnosis when intussusception is caused by a malignancy, such as Burkitt’s lymphoma, as the treatment of limited-stage Burkitt’s lymphoma has become very successful in recent years. Aim of the study The authors performed an analysis of all patients who presented to the clinic with intussusception caused by Burkitt’s lymphoma to determine whether there are characteristic symptoms in this group of patients that would enable faster implementation of oncological diagnostics. Case series Four patients with an average age of eight years presented with intussusception as the first sign of Burkitt’s lymphoma. They usually presented with a history of recurrent abdominal pain lasting for a few weeks. In three cases, a pathological lead point was visualized during the initial ultrasound examination. All of the patients were treated surgically. The stage of disease ranged from I to III, according to the St. Jude staging system. Conclusions Based on our small group of patients, we were able to observe some characteristic symptoms that are different from those most commonly seen in spontaneous intussusception: several weeks of recurrent abdominal pain, nausea, and vomiting. These observations are consistent with the spectrum and frequency of symptoms reported in the literature. The presence of a constellation of specific clinical features should allow clinicians to immediately suspect neoplastic diseases.

Background: The aim of the study was to assess prospectively the evolution of multiple clinical parameters throughout the first trimester of pregnancy. Method: A transvaginal ultrasound examination and a blood test was weekly performed until the 13th gestational week in a group of healthy volunteers. A total of 25 spontaneously conceived singleton pregnant women with good pregnancy outcome finally completed the study. The evolution of 10 transvaginal ultrasound parameters, 5 Doppler measurements and 6 serum parameters was studied.Results: An increasing trend with advancing gestation was evident for the mean gestational sac (MSD) and amniotic sac (AS) diameters, trophoblastic rim, CRL and serum progesterone. The uterine, umbilical and fetal cerebral arteries PI decreased with advancing gestation. The FM yolk sac (YS) diameter and b-hCG levels showed an initial rise and a final decrease. A great interindividual variation was evident for the b-hCG titer. The YS/CRL progressively approached to 0, whereas the MSD/CRL and the AS/MSD progressively approached to 1. The corpus luteum diameter, corpus luteum arteries PI, subehorionic arteries PI, complement levels (C3 and C4), platelet count and activated partial thromboplastin time experienced minimal changes. Conclusion: First trimester normograms for multiple clinical parameters are provided. P02The first results of the ultrasound transvaginal screening in early pregnancies in Kazan city, Tatarstan, Russia In 1 January 2000 in order of Tatarstan Health Care Ministry transvaginal first trimester screening was introduced in Kazan city. All pregnant women have to be examined in one of 5 the medical centers.We present the results of six month screening for all pregnant women between 10 and 14 weeks gestation. Method: Routine transvaginal ultrasound examination included the measurement of fetal crown-rump length, nuchal translucency and estimation of fetal anatomy. Results: A total 1620 pregnant women of 10±14 weeks of gestation were examined from January till June 2000. All abnormalities were detected at the 12±13 weeks gestational ages. The increasing of nuchal translucency thickness were found in 23 cases, 7 of them chromosomal defects had, in this group in 5 cases cystic hygroma with hydrops were identified.In 12 cases structural anomalies were found: 1-body stalk anomaly, 1 case-omphalocele with liver in it, 1-holoprosencephaly with proboshisis and microphtalmia, 1-encephalocele, 3-acrania, 5-anencephaly. In the cases of holoprosencephaly and encephalocele nuchal translucency measured at 10±11 week was normal. Conclusion: Even the first results of early pregnancy transvaginal screening show its great significance in our city. The most adequate period for transvaginal screening is 12±13 weeks. P03The value of ultrasound screening for fetal abnormalities in the first trimester Objective: Evaluation of routine screening in the early pregnancy by transvaginal sonography (TVS) in an unselected population. Design and methods: A routine ultrasound examination was offered to ...