We present an improvement of our own method for synthesising macrocyclic compounds via doubleamidation reactions of aromatic dimethyl esters with five oxa-aliphatic α,ω-diamines of different lengths, leading to a large library of potential ion receptors. We studied the influence of various inorganic salts (NaCl, KCl, CsCl, NH4Cl, MgSO4, CaCl2, CuSO4) on the macrocyclization reaction. The results were analyzed in terms of substrate conversion and distribution of products, using high performance liquid chromatography (HPLC).