Discoloration are symptoms of skin aging. They are connected with presence of melanin and lipofuscin, whose excess and abnormal distribution in the skin cause dark spots to appear. Melanin is formed under the influence of tyrosinase during melanogenesis. Its content changes with age, which may be a result of menopause. Lipofuscin is another example of the age pigment. It is composed of proteins, lipids and carbohydrates. It is described as an age pigment because its content increases with age. The formation and accumulation of lipofuscin is inevitable and leads to cell and homeostasis dysfunction because it reduces the proteasome activity.

Abstract

We conclude that seborrheic dermatitis is a dermatosis characterized by a cell type immune response with an important role of IFN-γ and IL-2.

Introduction: Langerhans cells (LCs) constitute a key component of the skin immune system (SIS Novocastra). Results: The number of LCs in the study group was lower in lesional skin compared to perilesional skin. After phototherapy we observed an increase in the number of LCs in lesional skin while a decrease of the LCs number was noted in perilesional skin

No abstract