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Background: There is not much data on matrix metalloproteinase neutrophil gelatinase-associated lipocalin (MMP-NGAL) complex in patients with atrial fibrillation (AF). Aim: The aim of the study was to assess the value of MMP-NGAL complex in predicting AF recurrence after electrical cardioversion. Methods: The serum levels of NGAL, cystatin C, interleukin-6, high-sensitivity C-reactive protein, copeptin, MMP-NGAL complex, matrix metalloproteinase 2, tissue inhibitor of metalloproteinase 1, Von Willebrand factor, B-type natriuretic peptide and the urinary level of NGAL were evaluated before cardioversion. Results: A total of 83 patients with persistent AF were enrolled in the study. Left atrial diameter (LA) ≥4.5 cm was significantly associated with AF recurrence at follow-up (p = 0.009). In selected 39 obese patients, MMP-NGAL complex was associated with AF recurrence (p = 0.03). If the concentration of MMP-NGAL complex increased by 1 ng/ml, the odds of AF recurrence increased by 4% (OR 1.04; CI: 1.00-1.08; p = 0.03). MMP-NGAL complex did not correlate with AF recurrence in patients with a first episode of AF, in patients ≥65 years of age and in patients with a LA ≥4.5 cm or with chronic kidney disease. Conclusions: It is known that the greater the BMI at baseline, the higher the likelihood of progression from paroxysmal to permanent AF. However, European Society of Cardiology (ESC) guidelines do not consider obese patients a population with a low likelihood of success of cardioversion. That is why we need a sensitive marker to predict sinus rhythm maintenance in such a population. We found that MMP-NGAL complex may predict AF recurrence after successful cardioversion in obese patients.

Results: Data are shown in the figure. Prevalence rates of AF in 2012 and 2013 in male individuals aged 70 to 74 years were significantly higher than the reference. The rate in male individuals aged 65 to 69 years in 2011 was higher than the reference with marginal significance. Conclusion:Prevalence rates of AF tentatively increased probably due to accelerated development of AF during and after the disaster and the prevalence rate became previous levels two-year after the disaster. Background: Increasing evidence suggests that sustained forms of atrial fibrillation (AF) are associated with worse outcomes, but long term follow-up data in unselected populations are lacking. In this study, we aimed to assess the risk for adverse events according to AF pattern in a large and unselected cohort of AF patients. Methods: We performed a prospective multicenter observational cohort study of 1540 AF patients. All patients completed questionnaires about personal characteristics and co-morbidities on a yearly basis. AF was classified into paroxysmal and non-paroxysmal AF. All outcomes were centrally validated and included incident hospitalization for congestive heart failure (HF), all-cause mortality and a combined outcome of stroke, myocardial infarction or cardiovascular death (MACE). Multivariable adjusted Cox regression analysis was performed to assess hazard according to AF pattern. Results: Mean age of the population was 69±11 years, paroxysmal AF was observed among 863 (56%) patients and non-paroxysmal among 677 (44%). During a mean follow-up of 3.3±1.4 years, 117, 139 and 150 cases of HF, MACE, and overall deaths occurred, respectively. Compared to patients with paroxysmal AF, patients with non-paroxysmal AF had a higher risk of death or cardiovascular events in age-and sex adjusted models, as shown in the Table. These relationships were substantially attenuated after multivariable adjustment (Table). Data are hazard ratios (HR) and 95% confidence intervals (95% CI) for the predictor nonparoxysmal atrial fibrillation. p-values were based on Cox-regression analysis. MACE was defined as either cardiovascular death or stroke or myocardial infarction. Multivariate models were adjusted for age, sex, body mass index, heart rate, history of hypertension, history of diabetes, history of coronary heart disease, history of stroke/TIA, history of heart failure, current smoking. P4611 | BEDSIDE Conclusions:In this large prospective cohort study, patients with nonparoxysmal AF had an increased risk of cardiovascular events and death compared to patients with paroxysmal AF. Background: About 30% of patients with atrial fibrillation (AF) suffer also from coronary artery disease (CAD). AF patients may present with chest pain, which can be accompanied by transient ischemic-type ST-segment changes sometimes with marginally elevated cardiac markers, thus mimicking symptoms of CAD. There is contradictory data on angiographic findings among patients with AF. The rate of significant CAD on angiography differs substantially from 4% to 19%...