A novel approach to the synthesis of optically pure 1-(2-aminoalkyl)aziridines via a nucleophilic ring-opening reaction of aziridine is presented. The reaction takes place under mild conditions in the presence of ZnBr 2 with moderate chemical yields. The formation of 1-(2-aminoalkyl)aziridines, starting from optically pure NHaziridines, occurs selectively, leading to a single diastereoisomer.
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