Global Burden of Disease Cancer Collaboration IMPORTANCE Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. OBJECTIVE To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. EVIDENCE REVIEW We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. FINDINGS In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs). CONCLUSIONS AND RELEVANCE The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equ...

Background. Jaundice in the neonate is one of the most common clinical problems. Globally, every year about 1.1 million babies develop it and the vast majority reside in sub-Saharan Africa and South Asia. Study on magnitude and local factors associated with neonatal jaundice is limited in Ethiopia. So this study was aimed at assessing magnitude and predictors of neonatal jaundice among neonates admitted to neonatal intensive care unit of public hospitals in Mekelle city, Northern Ethiopia. Methods. Institution based cross-sectional study was conducted from February to April 2016 in neonatal intensive care unit of Mekelle city public hospitals. Systematic random sampling technique was used to select study participants. Data was collected by interviewing mothers through structured questionnaire and reviewing neonates’ medical records using checklist. Multivariable binary logistic regression analyses were employed to identify factors associated with neonatal jaundice. Results. A total of 209 neonates with their mothers were included. The proportion of neonatal jaundice was found to be 37.3%. Prolonged labor [AOR = 4.39; 95% CI (1.8-10.69)], being male [AOR = 3.7; 95% CI (1.54-8.87)], maternal “O” blood group [AOR = 5.05; 95% CI (1.53-16.72)], sepsis [AOR = 2.64; 95% CI (1.15-6.05)], and blood type incompatibility [AOR = 18.21; 95% CI (6.36-52.13)] were positively associated with neonatal jaundice while night time delivery [AOR 0.42; 95% CI (0.18-0.96)] showed negative association. Conclusion. The magnitude of neonatal jaundice among neonates was found to be high. Duration of labor, time of delivery, sexes of neonate, sepsis, maternal blood group, and blood type incompatibility were significantly associated with neonatal jaundice. Therefore, improving newborn care and timely intervention for neonates with ABO/Rh incompatibility are recommended.

Background. Birth weight has a vital role in determining newborns survival in vulnerable conditions. Low birth weight is associated with fetal and neonatal morbidity and mortality, impairment of growth and development and also chronic disease later in life. This study was aimed to assess the magnitude of low birth weight and its determinants in Wolaita Sodo University teaching and referral hospital, southern Ethiopia. Methods. Institution based cross-sectional study was conducted from November to December 2018. Systematic random sampling technique was used to select study participants. Data was collected by interviewing mothers through structured questionnaire and reviewing neonates' medical records using a checklist. Multivariable binary logistic regression analyses were employed to identify factors associated with neonatal jaundice. Results. The proportion of low birth weight in the study area was found to be 15.8% (95% CI 11.7-19.9). Being primiparity [AOR=5.798; 95% (1.572-21.377)], anemia during pregnancy [AOR=3.808; 95% (1.513-9.586)], pregnancy induced hypertension [AOR= 6.955; 95% (2.386- 20.275)], intake herbal medication during pregnancy [AOR=35.762; 95% (4.571-279.764)], drinking alcohol during pregnancy [AOR=8.111; 95% (2.359-27. 895)] were predictors of low birth weight. Conclusion. The proportion of low birth weight among newborns delivered at Wolaita Sodo University teaching and referral hospital was comparable with the global prevalence of low birth weight. Parity, anemia, alcohol, herbal medication, and pregnancy-induced hypertension were significantly associated with low birth weight.

Background The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a global pandemic on 11th March, 2020. In Ethiopia, more than 90,490 and 1,300 confirmed cases and deaths were reported by the Federal Ministry of Health at the time of writing up this project. As health care providers are frontline workers managing the COVID-19 pandemic, this systematic review and meta-analysis aimed to assess the pooled level of knowledge, attitude, and practice towards COVID-19 among health professionals in Ethiopia. Methods PubMed, Google Scholar, Excerpta Medica database (EMBASE), Cochrane Library, Web of Science, and African Journal of Online (AJOL) were searched. The data were extracted using Microsoft Excel and analyzed using STATA version 14. Publication bias was checked by funnel plot and more objectively through Egger’s regression test, with P < 0.05 considered to indicate potential publication bias. The heterogeneity of studies was checked using I2 statistics. Pooled analysis was conducted using a weighted inverse variance random-effects model. Subgroup analysis was done related to geographic region and time. A leave-one-out sensitivity analysis was also employed. Result A total of 11 studies with 3,843 study participants for knowledge, eight studies with 2,842 study participants for attitude and 10 studies with 3, 435 study participants for practice were used to estimate the pooled level of good knowledge, positive attitude and poor practice among health professionals. The overall estimated good level of knowledge, positive attitude and poor practice towards COVID-19 was found to be 79.4% (95% CI: 73.5%-85.2%; I2 = 96%), 73.7% (95%CI: 63.09%-84.4%; I2 = 98.3%) and 40.3% (95%CI: 31.1%-49.6%; I2 = 97.1%) respectively. Conclusion Study findings showed that there were significant gaps in COVID-19 related knowledge, attitude and practice with respect to World Health Organization recommendations on COVID-19 management and personal protection practices. This study therefore recommends that institutions provide with immediate effect accurate and up-to-date information on COVID-19 and training that encourages improved knowledge, attitude and practice to mitigate this pandemic.

Background Mortality from preventable pregnancy-related complications remains high in Ethiopia. Antenatal care remains a major public health intervention that prevents maternal and neonatal mortality. Thus, this study aimed to assess the magnitude and determinants of adequate antenatal care utilization in Southern Ethiopia. Methods A community-based cross-sectional study was conducted between November and December 2019. A systematic random sampling technique was used to select 670 women. Data were collected using a pre-tested structured questionnaire administered with a digital survey tool (open data kit) and directly exported to STATA version 15 for analysis. Descriptive statistics followed by a multivariable logistic regression analysis were performed. Both crude and adjusted odds ratios (ORs) with 95% confidence intervals were reported. Results The magnitude of adequate antenatal care utilization was 23.13%. Tertiary and above education (AOR,4.15;95%CI: 1.95, 8.83), having the best friend who used maternal care (AOR,2.01;95%CI: 1.18,3.41), husband support (AOR,3.84; 95%CI: 1.05, 14.08), high wealth index (AOR,3.61; 95%CI: 1.86, 6.99), follow-up in private health facilities (AOR, 2.27;95% CI:1.33, 3.88), having a history of risky pregnancy (AOR,2.59; 95%CI: 1.55, 4.35), and planned pregnancy (AOR,2.60;95% CI: 1.35, 4.99) were significant determinants of overall adequate ANC service utilization. Conclusion The utilization of adequate antenatal care services is quite low. The study findings suggest that interventions should be in place to improve husband’s support, social networks, and women’s education. There is also a need to counsel women to utilize family planning.