Introduction: In Ethiopia, only one in ten reproductive-age women use long-acting reversible contraceptives. Evidence on the utilization of these methods and associated factors among sexually active reproductive-age women in the pastoral area of Northeast Ethiopia is limited. Thus, this study aimed to assess the utilization of long-acting reversible contraceptives and associated factors among sexually active reproductive-age women in the pastoral community of Northeast Ethiopia. Methods: A community-based cross-sectional study was conducted from 1 to 30 April 2021 among 572 reproductive-age women selected by a systematic random sampling method. Data were collected using a structured interviewer-administered questionnaire and entered into Epi-info version 7 and then finally exported to Stata version 16 for further analysis. Bivariable and multivariable binary logistic regression analyses were done to identify factors affecting the utilization of long-acting reversible contraceptives. Odds ratio with the corresponding 95% confidence interval were computed and the statistical significance of the explanatory variables was declared at p-value < 0.05. Results: Overall, the utilization of long-acting reversible contraceptives was (24.3%; 95% confidence interval = 20.9%–28.0%). It was also revealed that being Orthodox (adjusted odds ratio = 4.10; 95% confidence interval = 2.20–7.65) and Protestant (adjusted odds ratio = 7.86; 95% confidence interval = 1.26–18.97) religion followers, attending higher education (adjusted odds ratio = 3.31; 95% confidence interval = 1.37–7.98), and having a husband who attended higher education (adjusted odds ratio = 4.37; 95% confidence interval = 1.98–9.67) were associated with an increased odds of using long-acting reversible contraceptive methods. Besides, having a good (adjusted odds ratio = 6.69; 95% confidence interval = 2.64–16.95) and moderate (adjusted odds ratio = 3.03; 95% confidence interval = 1.06–8.56) knowledge, and positive attitude (adjusted odds ratio = 3.65; 95% confidence interval = 1.90–7.01) toward long-acting reversible contraceptives were also associated with the utilization of these methods. Conclusion: Less than one-fourth of sexually active reproductive-age women in the study area were using long-acting reversible contraceptives. Thus, improving women’s and husbands’ education and women’s knowledge and attitude toward long-acting reversible contraceptives is important to scale up the uptake of these contraceptive methods.