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Introduction:Recently there has been an increased association between environmental factors and male infertility. Aims: In the present study, the effect of changes in testicular biometric parameters (weight and volume) and testicular function (Sperm count, morphology, testosterone level) in Cadmium chloride administered Wistar rats was studied. Methodology: Twenty male albino Wistar rats were randomized into four groups (n=5). Group A (control) received rat chow and water, while Group B, C and D received 15mg/L, 20mg/L and 25mg/L of Cadmium chloride respectively for 6 weeks. Result: There was a significant (P=.05) and dose dependent decrease in testicular function parameters in the rats and a significant (P=.05) and positive correlation between the biometric parameters and testicular function. Conclusion:The findings showed that Cadmium chloride has a deleterious effect on testicular function and biometric parameters of the testes may be important in the assessment of testicular function.

ABSTRACT:The effect of bitter kola on the hepatotoxicity following mercury poisoning (mercuric chloride solution of 10ppm) was investigated in rats for a duration of six weeks. Thirty (30) acclimatized Wistar rats were divided into five groups(n=6).Group I served as control and were fed on normal rat chow and clean water ad libitum, group II received normal chow and mercury contaminated water (10ppm), group III animals were given clean water and 5% w/w bitter kola supplemented rat chow, group IV rats received bitter kola supplemented rat chow and mercury contaminated water, group V animals were placed for the first week of the experiment on mercury contaminated water and normal rat chow before substituting with clean water and bitter kola supplemented rat chow. Two (2) animals from each group were sacrificed at the end of 2 nd , 4 th and 6 th week and blood collected by cardiac puncture before the liver was harvested .Serum Alkaline phosphatase (ALP), Glutamate Oxaloacetate Transaminase (GOT), Glutamate Pyruvate Transaminase (GPT) and hepatic content of Mercury (Hg) were determined by standard laboratory methods. The results (Mean ± SEM) showed that G kola supplemented diet significantly lowered the hepatic mercury content as well as limited the hepatotoxic effects of the heavy metal indirectly assessed by measurement of the serum levels of alkaline phosphatase and the transaminases. @ JASEM