Computer-aided diagnosis (CAD) systems are considered a powerful tool for physicians to support identification of the novel Coronavirus Disease 2019 (COVID-19) using medical imaging modalities. Therefore, this article proposes a new framework of cascaded deep learning classifiers to enhance the performance of these CAD systems for highly suspected COVID-19 and pneumonia diseases in X-ray images. Our proposed deep learning framework constitutes two major advancements as follows. First, complicated multi-label classification of X-ray images have been simplified using a series of binary classifiers for each tested case of the health status. That mimics the clinical situation to diagnose potential diseases for a patient. Second, the cascaded architecture of COVID-19 and pneumonia classifiers is flexible to use different fine-tuned deep learning models simultaneously, achieving the best performance of confirming infected cases. This study includes eleven pre-trained convolutional neural network models, such as Visual Geometry Group Network (VGG) and Residual Neural Network (ResNet). They have been successfully tested and evaluated on public X-ray image dataset for normal and three diseased cases. The results of proposed cascaded classifiers showed that VGG16, ResNet50V2, and Dense Neural Network (DenseNet169) models achieved the best detection accuracy of COVID-19, viral (Non-COVID-19) pneumonia, and bacterial pneumonia images, respectively. Furthermore, the performance of our cascaded deep learning classifiers is superior to other multi-label classification methods of COVID-19 and pneumonia diseases in previous studies. Therefore, the proposed deep learning framework presents a good option to be applied in the clinical routine to assist the diagnostic procedures of COVID-19 infection.

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Today, there is a level of panic and chaos dominating the entire world due to the massive outbreak in the second wave of COVID-19 disease. As the disease has numerous symptoms ranging from a simple fever to the inability to breathe, which may lead to death. One of these symptoms is a cough which is considered one of the most common symptoms for COVID-19 disease. Recent research shows that the cough of a COVID-19 patient has distinct features that are different from other diseases. Consequently, the cough sound can be detected and classified to be used as a preliminary diagnosis of the COVID-19, which will help in reducing the spreading of that disease. The artificial intelligence (AI) engine can diagnose COVID-19 diseases by executing differential analysis of its inherent characteristics and comparing it to other non-COVID-19 coughs. However, the diagnosis of a COVID-19 infection by cough alone is an extremely challenging multidisciplinary problem. Therefore, this paper proposes a hybrid framework for efficiently COVID-19 detection and diagnosis using various ML algorithms from cough audio signals. The accuracy of this framework is improved with the utilization of the genetic algorithm with the ML techniques. We also assess the proposed system called CR19 for diagnosis on metrics such as precision, recall, F-measure. The results proved that the hybrid (GA-ML) technique provides superior results based on different evaluation metrics compared with ML approaches such as LR, LDA, KNN, CART, NB, and SVM. The proposed framework achieve an accuracy equal to 92.19%, 94.32%, 97.87%, 92.19%, 91.48%, and 93.61% in compared with the ML are 90.78, 92.90, 95.74, 87.94, 81.56, and 92.198 for LR, LDA, KNN, CART, NB, and SVM respectively. The proposed framework will efficiently help the physicians provide a proper medical decision regarding the COVID-19 analysis, thereby saving more lives. Therefore, this CR19 framework can be a clinical decision assistance tool used to channel clinical testing and treatment to those who need it the most, thereby saving more lives.

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