This study aimed to evaluate the frequency of diabetes mellitus in coronary artery disease patients and its association with the site of the atherosclerotic lesion. A comparative cross-sectional study was conducted in the Department of cardiology, CPE Institute of Cardiology,  Multan, from 20 August 2019 to 19 February 2020. A totalof 234 CAD patients referred for coronary angiography were selected for the study by non-probability consecutive sampling. All patients underwent coronary angiography. Diagnosis of proximal and distal atherosclerotic lesions and diabetes mellitus. All the data were analyzed by SPSS version 23. Diabetes was found in 77 (49%) patients with proximal lesions and 19 (20.90%) patients with mid to distal lesions. This difference was statistically significant with a p-value of <0.001. Of having age 53-70 years, 74 were found in proximal lesions, and 49 patients had mid todistal site lesions with a statistically insignificant p-value of 0.308. In females, 62 patients had proximal lesions, and 16 had mid to distal lesions. This difference was statistically significant with a p-value of <0.001. Stratification was also performed based on BMI, duration of CAD, hypertension, smoking, and family history of CAD. No significant association was found between these variables and the site of the lesion. Diabetes mellitus is significantly associatedwith the higher frequency of proximal lesions in coronary artery disease cases.

This study aimed to evaluate the relationship between TIMI risk score and the extent of coronary artery disease in non-STEMI patients. A descriptive prospective study was conducted in the Department of Cardiology of Chaudhary Pervez Elahi Institute of Cardiology, Multan, from 3rd June 2021-3rd June 2022. 237 patients admitted with NSTEMI within 7 days of admission were included. Baseline demographic characteristics were noted in a performed performance. The TIMI score for all patients was calculated. All patients underwent coronary angiography and the Gensini score was calculated. Average patients’ age was 54.44±9.10 years. The mean genuine score was 37.17±5.62, and the TIMI score was 3.93±1.42. There were 162 (68.35%) male and 75 (31.65%) female patients. Diabetes was found in 83 (35.02%) and hypertension in 124 (52.32%) patients. Family history of CAD was found in 54 (22.78%) patients, and hypercholesterolemia in 57 (22.05%) patients. TIMI score significantly correlated with Gensini score with a correlation coefficient (r) of 0.50 and p-value <0.0001. It is concluded that in NSTEMI patients, clinical risk stratification as determined by TIMI risk score is associated with the determined extent of the disease via the Gensini score.